Xue Xiali, Yang Xinwei, Deng Zhongyi
School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Ageing Res Rev. 2023 Mar;85:101837. doi: 10.1016/j.arr.2022.101837. Epub 2023 Jan 9.
Robot-assisted training is used as a new rehabilitation training method for the treatment of motor dysfunction in neurological diseases. Robot-assisted gait training (RAGT) has been reported to treat motor dysfunction in patients with Parkinson's disease (PD). The purpose of this study was to summarize previous clinical studies comparing the effectiveness of RAGT and conventional training for lower extremity dyskinesia in PD patients.
PubMed, Cochrane library, Scopus, Embase, EBSCO, Web of Science, CNKI, and Wanfang databases were searched. This study included all randomized controlled trials (RCTs) compared lower extremity RAGT with conventional training on motor impairment in PD patients. The retrieval time limit is from the establishment of the database to October 2022. Two researchers independently screened the literature, extracted data, assessed the risk of bias of included studies, and then used RevMan 5.3 software for meta-analysis.
A total of 14 RCTs with 572 patients were included. The results showed that compared with the control group, RAGT significantly improved the motor function evaluation-related indicators 10MWT, 6MWT, TUG and UPDRS III, 10MWT [MD= 0.08, 95 % CI (0.01, 0.14), P = 0.03], 6MWT [MD= 42.83, 95 % CI (22.05, 63.62), P < 0.0001], TUG[MD= -1.81, 95 % CI (-2.55, -1.08), P < 0.0001], UPDRS III [MD= - 3.82, 95 % CI (-4.27, -3.37), P < 0.00001]; For the balance function evaluation index BBS [MD= 3.33, 95 % CI (2.76, 3.89), P < 0.00001], the above results were significantly different significance.
The currently limited evidence suggests that RAGT provides evidence for the effectiveness of lower extremity motor function and balance dysfunction, and RAGT can significantly improve motor and balance function in PD patients.
机器人辅助训练作为一种新的康复训练方法，用于治疗神经系统疾病中的运动功能障碍。据报道，机器人辅助步态训练（RAGT）可治疗帕金森病（PD）患者的运动功能障碍。本研究的目的是总结以往比较RAGT与传统训练对PD患者下肢运动障碍疗效的临床研究。
检索PubMed、Cochrane图书馆、Scopus、Embase、EBSCO、Web of Science、CNKI和万方数据库。本研究纳入了所有比较下肢RAGT与传统训练对PD患者运动功能损害影响的随机对照试验（RCT）。检索时间范围为数据库建立至2022年10月。两名研究人员独立筛选文献、提取数据、评估纳入研究的偏倚风险，然后使用RevMan 5.3软件进行荟萃分析。
共纳入14项RCT，涉及572例患者。结果显示，与对照组相比，RAGT显著改善了运动功能评估相关指标10米步行试验（10MWT）、6分钟步行试验（6MWT）、起立行走试验（TUG）和统一帕金森病评定量表第三部分（UPDRS III），10MWT [平均差（MD）=0.08，95%置信区间（CI）（0.01，0.14），P = 0.03]，6MWT [MD = 42.83，95% CI（22.05，63.62），P < 0.0001]，TUG [MD = -1.81，95% CI（-2.55，-1.08），P < 0.0001]，UPDRS III [MD = -3.82，95% CI（-4.27，-3.37），P < 0.00001]；对于平衡功能评估指标Berg平衡量表（BBS）[MD = 3.33，95% CI（2.76，3.89），P < 0.00001]，上述结果差异均有统计学意义。
目前有限的证据表明，RAGT为改善下肢运动功能和平衡功能障碍的有效性提供了证据，RAGT可显著改善PD患者的运动和平衡功能。
