Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Am J Rhinol Allergy. 2023 Jul;37(4):495-501. doi: 10.1177/19458924221150977. Epub 2023 Jan 12.
There have been reports investigating the use of olfactory training in olfactory dysfunction after COVID-19.
We evaluated the effect of olfactory training on the olfactory dysfunction of patients infected with COVID-19.
We searched PubMed, EMBASE, the Web of Science, the Cochrane database, SCOPUS, and Google Scholar up to May 2022. We retrieved studies that compared the extents of olfactory dysfunction before and after olfactory training. We performed a subgroup analysis by the duration of olfactory dysfunction.
The olfactory score after olfactory training (standard mean difference [SMD] = 1.0830, 95% confidence interval [CI] [0.6416; 1.5245], < .0001, I = 90.4%) was higher than that before training. The olfactory dysfunction rate differed significantly (OR = 0.0232, 95% CI [0.0052; 0.1044], < .0001, I = 63.1%) before and after olfactory training. On subgroup analysis, although patients with both acute (onset < 30 days prior) and chronic (onset > 30 days prior) olfactory dysfunction evidenced clinically significant improvements, training during acute dysfunction (compared to acute dysfunction) increased the olfactory score to a greater extent (SMD = 1.7779, 95% CI [1.0077; 2.5481] vs 0.6928 [0.2143; 1.1712], = 0.0190). Moreover, as a result of subgroup analysis by dividing the included studies into2 using 2-month training period as standard, there was no statistically significant difference in the effect of the training period in the included study.
Olfactory training improved olfactory disorders caused by COVID-19. Such training was effective in both the acute and chronic phases.
已有研究报告探讨了嗅觉训练在 COVID-19 后嗅觉障碍中的应用。
评估嗅觉训练对 COVID-19 感染患者嗅觉障碍的影响。
我们检索了 PubMed、EMBASE、Web of Science、Cochrane 数据库、SCOPUS 和 Google Scholar，截至 2022 年 5 月。我们检索了比较嗅觉训练前后嗅觉障碍程度的研究。我们根据嗅觉障碍持续时间进行了亚组分析。
嗅觉训练后的嗅觉评分（标准均数差 [SMD] = 1.0830，95%置信区间 [CI] [0.6416; 1.5245]， <.0001，I = 90.4%）高于训练前。嗅觉障碍发生率在训练前后有显著差异（比值比 [OR] = 0.0232，95%CI [0.0052; 0.1044]， <.0001，I = 63.1%）。在亚组分析中，尽管急性（发病<30 天）和慢性（发病>30 天）嗅觉障碍患者均有明显的临床改善，但在急性障碍期间进行训练（与急性障碍相比）可更大程度地提高嗅觉评分（SMD = 1.7779，95%CI [1.0077; 2.5481] 比 0.6928 [0.2143; 1.1712]， = 0.0190）。此外，根据将纳入研究分为使用 2 个月训练期作为标准的 2 组进行亚组分析，纳入研究中训练期的效果没有统计学差异。
嗅觉训练改善了 COVID-19 引起的嗅觉障碍。这种训练在急性和慢性阶段都有效。
