Tehami Wafâa, Nani Abdelhafid, Khan Naim A, Hichami Aziz
Laboratory of Saharan Natural Resources, University of Ahmed Draia, Adrar, Algeria.
Physiologie de la Nutrition & Toxicologie, U1231 INSERM/Université de Bourgogne-Franche Comté (UBFC)/Agro-Sup, Dijon, France.
Dose Response. 2023 Jan 4;21(1):15593258221150704. doi: 10.1177/15593258221150704. eCollection 2023 Jan-Mar.
Colorectal cancer is considered the second most deadly cancer in the world. Studies have indicated that diet can prevent the risk of developing colorectal cancer. Recently, there has been an increasing interest in polyphenols due to their plausible effect on cancer prevention and treatment. -Coumaric acid (-CouA), a phenolic compound, is a cinnamic acid derivative found in several fruits, vegetables, and herbs. A growing body of evidence suggests that -CouA may be an effective agent for preventing and managing colorectal cancer. In this current review, we briefly highlight the bioavailability of -CouA. We also provide an up-to-date overview of molecular mechanisms underlying its anticancer effects, focusing on anti-inflammatory and antioxidant potentials, apoptosis induction, and cell cycle blockade. Finally, we discuss the impact of -CouA on clonogenicity and multidrug resistance of colorectal cancer cells.
结直肠癌被认为是世界上第二大致命癌症。研究表明，饮食可以预防结直肠癌的发生风险。最近，由于多酚类物质在癌症预防和治疗方面可能存在的作用，人们对其兴趣日益增加。对香豆酸（-CouA）是一种酚类化合物，是一种肉桂酸衍生物，存在于多种水果、蔬菜和草药中。越来越多的证据表明，-CouA可能是预防和管理结直肠癌的有效药物。在本综述中，我们简要强调了- CouA的生物利用度。我们还提供了其抗癌作用潜在分子机制的最新概述，重点关注抗炎和抗氧化潜力、诱导凋亡和细胞周期阻滞。最后，我们讨论了- CouA对结直肠癌细胞克隆形成能力和多药耐药性的影响。
