PET-CT Center, Fujian Medical University Union Hospital, Fuzhou, China.
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China.
Environ Res. 2023 Mar 15;221:115250. doi: 10.1016/j.envres.2023.115250. Epub 2023 Jan 14.
Diabetes mellitus is a growing disease that affects people of different ages due to deficiencies in insulin action and secretion. Diabetes causing long-term hyperglycemia damages, destroys, and fails essential organs, including kidneys, eyes, hearts, nerves, and blood vessels. The involvement of pathogenic factors makes diabetes mellitus a severe disease. The autoimmune process results in insulin deficiency by destroying the beta-cells in the pancreas. This leads to insulin resistance. As a result of defects and abnormalities in fat, carbohydrate, and protein synthesis, insulin does not work as it should on the target tissues. As diabetes mellitus becomes, more severe, long-term and effective treatment becomes necessary. A wide range of nanomaterials can be used to treat diabetes mellitus in patients. In addition to being potential imaging, diagnostic, and treatment agents for diabetes mellitus, carbon nanomaterials (CNMs) are another group of nanoparticles that exhibit potential interest. The CNMs acts as implantable nanosensor to track and detect blood glucose level in patients with diabetes. CNMS are possible drug carriers that can treat diabetes mellitus selectively, precisely, and effectively. Diabetes mellitus can be diagnosed and treated with CNMs due to their structural specificity and high drug-loading efficiency. The present review explores CNMs for their types, synthesis, and anti-diabetic properties. This review aims to provide a detailed view of the new technology that can be used to decipher the mechanism of CNMs in diabetes mellitus.
糖尿病是一种日益严重的疾病,由于胰岛素作用和分泌的缺陷,不同年龄段的人都会受到影响。糖尿病导致的长期高血糖会损害、破坏和衰竭包括肾脏、眼睛、心脏、神经和血管在内的重要器官。致病因素的参与使糖尿病成为一种严重的疾病。自身免疫过程通过破坏胰腺中的β细胞导致胰岛素缺乏。这会导致胰岛素抵抗。由于脂肪、碳水化合物和蛋白质合成的缺陷和异常,胰岛素不能在靶组织中正常发挥作用。随着糖尿病变得更加严重,需要长期有效的治疗。各种纳米材料可用于治疗糖尿病患者。除了作为糖尿病的潜在成像、诊断和治疗剂外,碳纳米材料(CNMs)是另一组具有潜在兴趣的纳米颗粒。CNMs 作为可植入纳米传感器,可跟踪和检测糖尿病患者的血糖水平。CNMs 可以作为可能的药物载体,有选择性、精确性和有效性地治疗糖尿病。由于其结构特异性和高载药效率,CNMs 可用于诊断和治疗糖尿病。本综述探讨了 CNMs 的类型、合成和抗糖尿病特性。本综述旨在提供对可用于破解 CNMs 在糖尿病中作用机制的新技术的详细了解。