Rotterdam E P, Katan M B, Knuiman J T
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
Clin Chem. 1987 Oct;33(10):1913-5.
We studied intra-individual variation in total and high-density lipoprotein (HDL) cholesterol in healthy volunteers (22 men and 19 women, ages 19 to 62 years) on controlled natural diets. The within-person coefficient of variation (CV) depended on the interval between blood samples, increasing from about 2% to 3% for measurements made 24 h apart to 4% to 5% for measurements made at four-day intervals or longer. We conclude that within-subject fluctuations in total and HDL cholesterol have a time constant of several days. Multiple measurements are generally needed to decide whether an asymptomatic subject exceeds a certain concentration of total or HDL cholesterol; we recommend that such measurements be made at least four days apart.
我们研究了健康志愿者（22名男性和19名女性，年龄19至62岁）在控制自然饮食情况下，总胆固醇和高密度脂蛋白（HDL）胆固醇的个体内变异。个体内变异系数（CV）取决于血样采集间隔，间隔24小时的测量值，CV从约2%增至3%，间隔四天或更长时间的测量值，CV则为4%至5%。我们得出结论，总胆固醇和HDL胆固醇的个体内波动具有几天的时间常数。通常需要多次测量才能确定无症状个体的总胆固醇或HDL胆固醇浓度是否超过特定水平；我们建议此类测量至少间隔四天进行。
