大小在非经典炎性小体激活和细胞介导免疫中起重要作用。
Size matters in non-canonical inflammasome activation and cell-mediated immunity.
机构信息
Pritzker School of Molecular Engineering, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA.
Pritzker School of Molecular Engineering, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA.
出版信息
Cell Rep Med. 2023 Jan 17;4(1):100904. doi: 10.1016/j.xcrm.2022.100904.
Abstract
Particulate adjuvants are key components of many approved vaccines, but their mechanism of adjuvanticity is debated. Muñoz-Wolf et al. find that 50-nm particles maximize cell-mediated immune responses by activating the caspase-11 inflammasome, providing mechanistic insight to particulate adjuvant technologies.
摘要
颗粒佐剂是许多已批准疫苗的关键组成部分，但它们的佐剂机制仍存在争议。Muñoz-Wolf 等人发现，50nm 颗粒通过激活半胱天冬酶-11 炎性小体来最大程度地提高细胞介导的免疫反应，为颗粒佐剂技术提供了机制见解。
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