Maekawa A, Onodera H, Tanigawa H, Kanno J, Furuta K, Hayashi Y
J Cancer Res Clin Oncol. 1986;111(2):173-6. doi: 10.1007/BF00400760.
Relatively high incidences of Sertoli cell tumors of the ovary were induced in Donryu rats given a 400 ppm N-ethyl-N-nitrosourea solution as drinking water for 4 weeks or a single dose of 200 mg/kg N-propyl-N-nitrosourea by stomach tube. Typical Sertoli cell tumors were composed of solid areas showing tubular formation. Tubules were lined by tall, columnar cells having abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented round nuclei. In some cases, Sertoli cell tumors were found to be mixed with granulosa cell tumors.
给雄性唐利育大鼠饮用4周含400 ppm N-乙基-N-亚硝基脲的溶液，或经胃管单次给予200 mg/kg N-丙基-N-亚硝基脲，可诱导出相对较高发生率的卵巢支持细胞瘤。典型的支持细胞瘤由显示管状结构的实性区域组成。小管由高柱状细胞排列而成，这些细胞具有丰富的、轻度嗜酸性的、常呈空泡状的细胞质，以及位于基部的圆形细胞核。在某些情况下，发现支持细胞瘤与颗粒细胞瘤混合存在。
