Maronpot R R
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Environ Health Perspect. 1987 Aug;73:125-30. doi: 10.1289/ehp.8773125.
Ovarian toxicity and/or carcinogenicity has been documented for at least eight chemicals recently tested in National Toxicity Program prechronic and chronic rodent studies. The chemicals that yielded treatment-related ovarian lesions were 1,3-butadiene, 4-vinylcyclohexene, vinylcyclohexene deipoxide, nitrofurantoin, nitrofurazone, benzene, delta-9-tetrahydrocannabinol, and tricresylphosphate. Typical nonneoplastic ovarian changes included hypoplasia, atrophy, follicular necrosis, and tubular hyperplasia. The most commonly observed treatment-related neoplasms were granulosa cell tumors and benign mixed tumors. A relationship between antecedent ovarian hypoplasia, atrophy, and hyperplasia and subsequent ovarian neoplasia is supported by some of these National Toxicology Program studies. Pathologic changes in other tissues such as the adrenal glands and uterus were associated with the treatment-related ovarian changes.
在国家毒理学计划开展的啮齿动物亚慢性和慢性研究中，最近对至少八种化学物质进行了测试，已证实它们具有卵巢毒性和/或致癌性。产生与治疗相关卵巢病变的化学物质有1,3 - 丁二烯、4 - 乙烯基环己烯、乙烯基环己烯二环氧化物、呋喃妥因、呋喃西林、苯、δ-9 - 四氢大麻酚和磷酸三甲苯酯。典型的非肿瘤性卵巢变化包括发育不全、萎缩、卵泡坏死和管状增生。最常观察到的与治疗相关的肿瘤是颗粒细胞瘤和良性混合瘤。国家毒理学计划的一些研究支持了先前的卵巢发育不全、萎缩和增生与随后的卵巢肿瘤之间的关联。肾上腺和子宫等其他组织的病理变化与治疗相关的卵巢变化有关。
