Kang Jiannan, Fan Xiwang, Zhong Yiwen, Casanova Manuel F, Sokhadze Estate M, Li Xiaoli, Niu Zikang, Geng Xinling
College of Electronic & Information Engineering, Hebei University, Baoding 071000, China.
Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai 200124, China.
Bioengineering (Basel). 2023 Jan 11;10(1):98. doi: 10.3390/bioengineering10010098.
Autism spectrum disorder (ASD) is a heterogeneous disorder that affects several behavioral domains of neurodevelopment. Transcranial direct current stimulation (tDCS) is a new method that modulates motor and cognitive function and may have potential applications in ASD treatment. To identify its potential effects on ASD, differences in electroencephalogram (EEG) microstates were compared between children with typical development ( = 26) and those with ASD ( = 26). Furthermore, children with ASD were divided into a tDCS (experimental) and sham stimulation (control) group, and EEG microstates and Autism Behavior Checklist (ABC) scores before and after tDCS were compared. Microstates A, B, and D differed significantly between children with TD and those with ASD. In the experimental group, the scores of microstates A and C and ABC before tDCS differed from those after tDCS. Conversely, in the control group, neither the EEG microstates nor the ABC scores before the treatment period (sham stimulation) differed from those after the treatment period. This study indicates that tDCS may become a viable treatment for ASD.
自闭症谱系障碍（ASD）是一种影响神经发育多个行为领域的异质性疾病。经颅直流电刺激（tDCS）是一种调节运动和认知功能的新方法，可能在ASD治疗中具有潜在应用。为了确定其对ASD的潜在影响，比较了典型发育儿童（n = 26）和ASD儿童（n = 26）之间脑电图（EEG）微状态的差异。此外，将ASD儿童分为tDCS（实验组）和假刺激（对照组）组，并比较了tDCS前后的EEG微状态和自闭症行为检查表（ABC）评分。TD儿童和ASD儿童之间的微状态A、B和D有显著差异。在实验组中，tDCS前微状态A和C的评分以及ABC评分与tDCS后不同。相反，在对照组中，治疗期（假刺激）前的EEG微状态和ABC评分与治疗期后均无差异。这项研究表明，tDCS可能成为ASD的一种可行治疗方法。
