• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

具有衰老特征的免疫途径改善了人类癌症的免疫治疗效果和药物预测

Immune Pathways with Aging Characteristics Improve Immunotherapy Benefits and Drug Prediction in Human Cancer.

作者信息

Wang Xinyue, Guo Shuang, Zhou Hanxiao, Sun Yue, Gan Jing, Zhang Yakun, Zheng Wen, Zhang Caiyu, Zhao Xiaoxi, Xiao Jiebin, Wang Li, Gao Yue, Ning Shangwei

机构信息

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.

出版信息

Cancers (Basel). 2023 Jan 4;15(2):342. doi: 10.3390/cancers15020342.

DOI:10.3390/cancers15020342
PMID:36672292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9856581/
Abstract

(1) Background: Perturbation of immune-related pathways can make substantial contributions to cancer. However, whether and how the aging process affects immune-related pathways during tumorigenesis remains largely unexplored. (2) Methods: Here, we comprehensively investigated the immune-related genes and pathways among 25 cancer types using genomic and transcriptomic data. (3) Results: We identified several pathways that showed aging-related characteristics in various cancers, further validated by conventional aging-related gene sets. Genomic analysis revealed high mutation burdens in cytokines and cytokines receptors pathways, which were strongly correlated with aging in diverse cancers. Moreover, immune-related pathways were found to be favorable prognostic factors in melanoma. Furthermore, the expression level of these pathways had close associations with patient response to immune checkpoint blockade therapy in melanoma and non-small cell lung cancer. Applying a net-work-based method, we predicted immune- and aging-related genes in pan-cancer and utilized these genes for potential immunotherapy drug discovery. Mapping drug target data to our top-ranked genes identified potential drug targets, FYN, JUN, and SRC. (4) Conclusions: Taken together, our systematic study helped interpret the associations among immune-related pathways, aging, and cancer and could serve as a resource for promoting clinical treatment.

摘要

（1）背景：免疫相关通路的扰动对癌症有重大影响。然而，衰老过程在肿瘤发生过程中是否以及如何影响免疫相关通路在很大程度上仍未得到探索。（2）方法：在此，我们使用基因组和转录组数据全面研究了25种癌症类型中的免疫相关基因和通路。（3）结果：我们鉴定出了几种在各种癌症中表现出与衰老相关特征的通路，并通过传统的衰老相关基因集进一步验证。基因组分析揭示了细胞因子和细胞因子受体通路中的高突变负担，这在多种癌症中与衰老密切相关。此外发现免疫相关通路是黑色素瘤的有利预后因素。此外，这些通路的表达水平与黑色素瘤和非小细胞肺癌患者对免疫检查点阻断疗法的反应密切相关。应用基于网络的方法，我们预测了泛癌中免疫和衰老相关基因，并利用这些基因进行潜在免疫治疗药物的发现。将药物靶点数据映射到我们排名靠前的基因上，确定了潜在的药物靶点FYN、JUN和SRC。（4）结论：综上所述，我们的系统研究有助于解释免疫相关通路、衰老和癌症之间的关联，并可作为促进临床治疗的资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/5b42c9536ac3/cancers-15-00342-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/e2f5acdb0dea/cancers-15-00342-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/89fed5b285b4/cancers-15-00342-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/2f8c807f7caf/cancers-15-00342-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/61e14752ae14/cancers-15-00342-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/358ec6b9d690/cancers-15-00342-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/f14c0cdd8a2a/cancers-15-00342-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/5b42c9536ac3/cancers-15-00342-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/e2f5acdb0dea/cancers-15-00342-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/89fed5b285b4/cancers-15-00342-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/2f8c807f7caf/cancers-15-00342-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/61e14752ae14/cancers-15-00342-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/358ec6b9d690/cancers-15-00342-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/f14c0cdd8a2a/cancers-15-00342-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/416d/9856581/5b42c9536ac3/cancers-15-00342-g007.jpg

相似文献

1
Immune Pathways with Aging Characteristics Improve Immunotherapy Benefits and Drug Prediction in Human Cancer.具有衰老特征的免疫途径改善了人类癌症的免疫治疗效果和药物预测
Cancers (Basel). 2023 Jan 4;15(2):342. doi: 10.3390/cancers15020342.
2
Pan-cancer transcriptomic analysis identified six classes of immunosenescence genes revealed molecular links between aging, immune system and cancer.泛癌症转录组分析确定了 6 类免疫衰老基因，揭示了衰老、免疫系统和癌症之间的分子联系。
Genes Immun. 2023 Apr;24(2):81-91. doi: 10.1038/s41435-023-00197-9. Epub 2023 Feb 17.
3
Identification of SHCBP1 as a potential biomarker involving diagnosis, prognosis, and tumor immune microenvironment across multiple cancers.鉴定SHCBP1作为一种潜在的生物标志物，涉及多种癌症的诊断、预后及肿瘤免疫微环境。
Comput Struct Biotechnol J. 2022 Jun 18;20:3106-3119. doi: 10.1016/j.csbj.2022.06.039. eCollection 2022.
4
Pan-cancer analysis of CREB3L1 as biomarker in the prediction of prognosis and immunotherapeutic efficacy.CREB3L1作为生物标志物在预后预测和免疫治疗疗效中的泛癌分析
Front Genet. 2022 Sep 9;13:938510. doi: 10.3389/fgene.2022.938510. eCollection 2022.
5
Pan-cancer analysis reveals RIPK2 predicts prognosis and promotes immune therapy resistance via triggering cytotoxic T lymphocytes dysfunction.泛癌症分析显示 RIPK2 通过触发细胞毒性 T 淋巴细胞功能障碍预测预后并促进免疫治疗耐药性。
Mol Med. 2022 May 4;28(1):47. doi: 10.1186/s10020-022-00475-8.
6
Derivation and Comprehensive Analysis of Aging Patterns in Patients with Bladder Cancer.膀胱癌患者衰老模式的推导与综合分析
Dis Markers. 2021 Oct 21;2021:3385058. doi: 10.1155/2021/3385058. eCollection 2021.
7
Comprehensive alteration-related transcriptomic characterization is involved in immune infiltration and correlated with prognosis and immunotherapy response of bladder cancer.全面的改变相关转录组学特征与膀胱癌的免疫浸润相关，并与预后和免疫治疗反应相关。
Front Immunol. 2022 Jul 26;13:931906. doi: 10.3389/fimmu.2022.931906. eCollection 2022.
8
Identification of Hypoxia-Related Subtypes, Establishment of Prognostic Models, and Characteristics of Tumor Microenvironment Infiltration in Colon Cancer.结肠癌中缺氧相关亚型的鉴定、预后模型的建立及肿瘤微环境浸润特征
Front Genet. 2022 Jun 17;13:919389. doi: 10.3389/fgene.2022.919389. eCollection 2022.
9
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.泛癌分析 PARP1 改变作为预测免疫治疗效果的生物标志物及其表达水平与免疫治疗特征的关联。
Front Immunol. 2021 Aug 31;12:721030. doi: 10.3389/fimmu.2021.721030. eCollection 2021.
10
An aging-related signature predicts favorable outcome and immunogenicity in lung adenocarcinoma.衰老相关特征可预测肺腺癌的预后和免疫原性。
Cancer Sci. 2022 Mar;113(3):891-903. doi: 10.1111/cas.15254. Epub 2022 Jan 7.

引用本文的文献

1
Exploration in association between vitamin D and cutaneous melanoma and explainable machine learning prediction.维生素D与皮肤黑色素瘤之间的关联探索及可解释机器学习预测
Front Oncol. 2025 May 8;15:1503611. doi: 10.3389/fonc.2025.1503611. eCollection 2025.
2
Predicting the Prognosis of Bladder Cancer Patients Through Integrated Multi-omics Exploration of Chemotherapy-Related Hypoxia Genes.通过化疗相关缺氧基因的综合多组学探索预测膀胱癌患者的预后
Mol Biotechnol. 2025 Jun;67(6):2367-2381. doi: 10.1007/s12033-024-01203-9. Epub 2024 May 28.
3
Emerging trends in clinical cancer genomic research.

本文引用的文献

1
Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4 T cells.间充质干细胞的成骨分化促进 c-Jun 依赖性白细胞介素 8 的分泌，并介导 CD4 T 细胞的迁移和分化。
Stem Cell Res Ther. 2022 Feb 5;13(1):58. doi: 10.1186/s13287-022-02735-0.
2
Hallmarks of response, resistance, and toxicity to immune checkpoint blockade.免疫检查点阻断反应、耐药性和毒性的特征。
Cell. 2022 Feb 3;185(3):576. doi: 10.1016/j.cell.2022.01.008.
3
Mechanisms of immune activation and regulation: lessons from melanoma.
临床癌症基因组研究的新趋势
Cancer Biol Med. 2023 Nov 28;20(11):783-7. doi: 10.20892/j.issn.2095-3941.2023.0383.
免疫激活和调节的机制：黑色素瘤的启示。
Nat Rev Cancer. 2022 Apr;22(4):195-207. doi: 10.1038/s41568-022-00442-9. Epub 2022 Feb 1.
4
Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association.利用全球基因网络关联预测抗 PD-1 免疫治疗的生物标志物和治疗组合。
Nat Commun. 2022 Jan 10;13(1):42. doi: 10.1038/s41467-021-27651-4.
5
Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 T cell clone size and cytotoxicity.免疫检查点阻断敏感性和无进展生存期与基线 CD8 T 细胞克隆大小和细胞毒性相关。
Sci Immunol. 2021 Oct;6(64):eabj8825. doi: 10.1126/sciimmunol.abj8825. Epub 2021 Oct 1.
6
Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength.抗原和检查点受体的结合重新校准了 T 细胞受体信号强度。
Immunity. 2021 Nov 9;54(11):2481-2496.e6. doi: 10.1016/j.immuni.2021.08.020. Epub 2021 Sep 16.
7
Dasatinib enhances anti-leukemia efficacy of chimeric antigen receptor T cells by inhibiting cell differentiation and exhaustion.达沙替尼通过抑制细胞分化和耗竭增强嵌合抗原受体 T 细胞的抗白血病疗效。
J Hematol Oncol. 2021 Jul 21;14(1):113. doi: 10.1186/s13045-021-01117-y.
8
Targeting immune dysfunction in aging.靶向衰老相关的免疫功能障碍。
Ageing Res Rev. 2021 Sep;70:101410. doi: 10.1016/j.arr.2021.101410. Epub 2021 Jul 17.
9
Immune Aging and Immunotherapy in Cancer.免疫衰老与癌症的免疫治疗。
Int J Mol Sci. 2021 Jun 29;22(13):7016. doi: 10.3390/ijms22137016.
10
Senescence and Aging: Does It Impact Cancer Immunotherapies?衰老与老化：它会影响癌症免疫疗法吗？
Cells. 2021 Jun 22;10(7):1568. doi: 10.3390/cells10071568.