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磁性 CS/PVA/HA/pSPIONs 支架的制备及体外特性研究——用于磁热疗和骨再生。

Preparation and In Vitro Characterization of Magnetic CS/PVA/HA/pSPIONs Scaffolds for Magnetic Hyperthermia and Bone Regeneration.

机构信息

i3N/CENIMAT, Department of Materials Science, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal.

i3N/CENIMAT, Department of Physics, NOVA School of Science and Technology, Campus de Caparica, 2829-516 Caparica, Portugal.

出版信息

Int J Mol Sci. 2023 Jan 6;24(2):1128. doi: 10.3390/ijms24021128.

DOI:10.3390/ijms24021128
PMID:36674644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9863008/
Abstract

Conventional bone cancer treatment often results in unwanted side effects, critical-sized bone defects, and inefficient cancer-cell targeting. Therefore, new approaches are necessary to better address bone cancer treatment and patient's recovery. One solution may reside in the combination of bone regeneration scaffolds with magnetic hyperthermia. By incorporating pristine superparamagnetic iron oxide nanoparticles (pSPIONs) into additively manufactured scaffolds we created magnetic structures for magnetic hyperthermia and bone regeneration. For this, hydroxyapatite (HA) particles were integrated in a polymeric matrix composed of chitosan (CS) and poly (vinyl alcohol) (PVA). Once optimized, pSPIONs were added to the CS/PVA/HA paste at three different concentrations (1.92, 3.77, and 5.54 wt.%), and subsequently additively manufactured to form a scaffold. Results indicate that scaffolds containing 3.77 and 5.54 wt.% of pSPIONs, attained temperature increases of 6.6 and 7.5 °C in magnetic hyperthermia testing, respectively. In vitro studies using human osteosarcoma Saos-2 cells indicated that pSPIONs incorporation significantly stimulated cell adhesion, proliferation and alkaline phosphatase (ALP) expression when compared to CS/PVA/HA scaffolds. Thus, these results support that CS/PVA/HA/pSPIONs scaffolds with pSPIONs concentrations above or equal to 3.77 wt.% have the potential to be used for magnetic hyperthermia and bone regeneration.

摘要

传统的骨癌治疗方法常常导致不可取的副作用、临界尺寸的骨缺损和低效的癌细胞靶向。因此，需要新的方法来更好地解决骨癌治疗和患者康复的问题。一种解决方案可能在于将骨再生支架与磁热疗相结合。通过将原始超顺磁氧化铁纳米粒子（pSPIONs）纳入增材制造的支架中，我们为磁热疗和骨再生创建了磁性结构。为此，将羟基磷灰石（HA）颗粒整合到由壳聚糖（CS）和聚乙烯醇（PVA）组成的聚合物基质中。一旦优化，pSPIONs 就会以三种不同浓度（1.92、3.77 和 5.54wt.%）添加到 CS/PVA/HA 糊剂中，然后通过增材制造形成支架。结果表明，在磁热疗测试中，分别含有 3.77 和 5.54wt.%pSPIONs 的支架实现了 6.6 和 7.5°C 的温度升高。使用人骨肉瘤 Saos-2 细胞的体外研究表明，与 CS/PVA/HA 支架相比，pSPIONs 的掺入显著刺激了细胞黏附、增殖和碱性磷酸酶（ALP）的表达。因此，这些结果表明，CS/PVA/HA/pSPIONs 支架中 pSPIONs 的浓度高于或等于 3.77wt.%时，有可能用于磁热疗和骨再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/775e2ba7e38f/ijms-24-01128-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/265aa0810975/ijms-24-01128-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/683ac42c82e4/ijms-24-01128-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/6a40f445771a/ijms-24-01128-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/4f2fac0cc943/ijms-24-01128-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/464d1c236f6f/ijms-24-01128-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/172de503e2c3/ijms-24-01128-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/5e503fd891d7/ijms-24-01128-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/1034d44191b5/ijms-24-01128-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/63748975f1d0/ijms-24-01128-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/775e2ba7e38f/ijms-24-01128-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/265aa0810975/ijms-24-01128-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/683ac42c82e4/ijms-24-01128-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/6a40f445771a/ijms-24-01128-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/4f2fac0cc943/ijms-24-01128-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/464d1c236f6f/ijms-24-01128-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/172de503e2c3/ijms-24-01128-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/5e503fd891d7/ijms-24-01128-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/1034d44191b5/ijms-24-01128-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/63748975f1d0/ijms-24-01128-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/609c/9863008/775e2ba7e38f/ijms-24-01128-g010.jpg

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A Review on Damage and Rupture Modelling for Soft Tissues.

Bioengineering (Basel). 2022-1-10

[2]
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Mater Sci Eng C Mater Biol Appl. 2021-9

[3]
Physically-cross-linked poly(vinyl alcohol) cell culture plate coatings facilitate preservation of cell-cell interactions, spheroid formation, and stemness.

J Biomed Mater Res B Appl Biomater. 2021-11

[4]
Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds.

Macromol Biosci. 2021-4

[5]
The rheology of direct and suspended extrusion bioprinting.

APL Bioeng. 2021-2-4

[6]
Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche.

Sci Rep. 2020-12-18

[7]
Tailoring of the rheological properties of bioinks to improve bioprinting and bioassembly for tissue replacement.

Biochim Biophys Acta Gen Subj. 2021-2

[8]
Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends.

Materials (Basel). 2020-6-11

[9]
3D-printed magnetic FeO/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia.

J Mater Chem B. 2014-11-21

[10]
Biomimetic and mesoporous nano-hydroxyapatite for bone tissue application: a short review.

Biomed Mater. 2020-2-27

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