Taha Marwa S, Hagras Maha M, Shalaby Marwa M, Zamzam Yosra Abdelmonem, Elkolaly Reham M, Abdelwahab Marwa A, Maxwell Sara Youssef
Department of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta 31527, Egypt.
Pathogens. 2023 Jan 11;12(1):121. doi: 10.3390/pathogens12010121.
Globally, () has been identified as a serious source of infections. The objectives of our study were to investigate the prevalence of multidrug-resistant (MDR) in Tanta University Hospitals, Gharbia Governorate, Egypt; characterize their carbapenem resistance profiles; and identify their different capsular serotypes. We identified and isolated 160 (32%) from 500 different clinical samples, performed antimicrobial susceptibility testing, and then used multiplex PCR to detect carbapenemase genes and capsular serotypes K1, K2, K3, K5, K20, K54, and K57. We detected phenotypic carbapenem resistance in 31.3% (50/160) of the isolates; however, molecular assays revealed that 38.75% (62/160) of isolates were carrying carbapenemase-encoding genes. Generally, was the prevalent gene (15.5%), followed by (15%), (7.5%), (4%), and (3.8%). and correlated with phenotypic resistance in 91.67% and 88% of the isolates that harbored them, respectively. Capsular typing showed that the most prevalent pathotype was K1 (30.6%), followed by K57 (24.2%), K54 (19.35%), K20 (9.67%), and K2 (6.45%). A critical risk to community health is posed by the high incidence of multidrug-resistant (MDR) virulent isolates from our hospital, and our study examines this pathogen's public health and epidemiological risks.
在全球范围内，（）已被确定为严重的感染源。我们研究的目的是调查埃及盖勒尤比省坦塔大学医院中多重耐药（MDR）（）的流行情况；描述其对碳青霉烯类抗生素的耐药谱；并确定其不同的荚膜血清型。我们从500份不同的临床样本中鉴定并分离出160株（32%）（），进行了抗菌药物敏感性测试，然后使用多重PCR检测碳青霉烯酶基因以及荚膜血清型K1、K2、K3、K5、K20、K54和K57。我们在31.3%（50/160）的分离株中检测到表型碳青霉烯耐药性；然而，分子检测显示38.75%（62/160）的分离株携带碳青霉烯酶编码基因。一般来说，（）是最常见的基因（15.5%），其次是（）（15%）、（）（7.5%）、（）（4%）和（）（3.8%）。（）和（）分别与携带它们的分离株中91.67%和88%的表型耐药相关。荚膜分型显示最常见的致病型是K1（30.6%），其次是K57（24.2%）、K54（19.35%）、K20（9.67%）和K2（6.45%）。我院多重耐药（MDR）强毒（）分离株的高发生率对社区健康构成了重大风险，我们的研究调查了这种病原体的公共卫生和流行病学风险。
需注意，原文括号处有信息缺失，以上译文是在尽量还原原文基础上完成的。
