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胡椒碱通过下调环氧化酶2途径降低宫颈癌细胞的肿瘤进展。

Piperine Reduces Neoplastic Progression in Cervical Cancer Cells by Downregulating the Cyclooxygenase 2 Pathway.

作者信息

Cardoso Luana Pereira, de Sousa Stefanie Oliveira, Gusson-Zanetoni Juliana Prado, de Melo Moreira Silva Laura Luciana, Frigieri Barbara Maria, Henrique Tiago, Tajara Eloiza Helena, Oliani Sonia Maria, Rodrigues-Lisoni Flávia Cristina

机构信息

São Paulo State University (Unesp), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, 15054-000, Brazil, Department of Biology Science.

Department of Molecular Biology, School of Medicine of Sao José do Rio Preto (FAMERP), Sao José do Rio Preto 15090-000, Brazil.

出版信息

Pharmaceuticals (Basel). 2023 Jan 10;16(1):103. doi: 10.3390/ph16010103.

DOI:10.3390/ph16010103
PMID:36678600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9866887/
Abstract

Cervical cancer is the fourth-most common type of cancer in the world that causes death in women. It is mainly caused by persistent infection by human papillomavirus (HPV) that triggers a chronic inflammatory process. Therefore, the use of anti-inflammatory drugs is a potential treatment option. The effects of piperine, an amino alkaloid derived from , are poorly understood in cervical cancer inflammation, making it a target of research. This work aimed to investigate the antitumor effect of piperine on cervical cancer and to determine whether this effect is modulated by the cyclooxygenase 2 (PTGS2) pathway using in vitro model of cervical cancer (HeLa, SiHa, CaSki), and non-tumoral (HaCaT) cell lines. The results showed that piperine reduces in vitro parameters associated with neoplastic evolution such as proliferation, viability and migration by cell cycle arrest in the G1/G0 and G2/M phases, with subsequent induction of apoptosis. This action was modulated by downregulation of cyclooxygenase 2 (PTGS2) pathway, which in turn regulates the secretion of cytokines and the expression of mitogen-activated protein kinases (MAPKs), metalloproteinases (MMPs), and their antagonists (TIMPs). These findings indicate the phytotherapeutic potential of piperine as complementary treatment in cervical cancer.

摘要

宫颈癌是全球导致女性死亡的第四大常见癌症类型。它主要由人乳头瘤病毒（HPV）持续感染引发慢性炎症过程所致。因此，使用抗炎药物是一种潜在的治疗选择。胡椒碱是一种源自[此处原文缺失相关来源信息]的氨基生物碱，其在宫颈癌炎症中的作用尚不清楚，这使其成为研究对象。本研究旨在利用宫颈癌体外模型（HeLa、SiHa、CaSki）和非肿瘤（HaCaT）细胞系，研究胡椒碱对宫颈癌的抗肿瘤作用，并确定这种作用是否由环氧合酶2（PTGS2）途径介导。结果表明，胡椒碱通过使细胞周期停滞在G1/G0和G2/M期，降低与肿瘤进展相关的体外参数，如增殖、活力和迁移，随后诱导细胞凋亡。这种作用通过下调环氧合酶2（PTGS2）途径来调节，该途径进而调节细胞因子的分泌以及丝裂原活化蛋白激酶（MAPKs）、金属蛋白酶（MMPs）及其拮抗剂（TIMPs）的表达。这些发现表明胡椒碱作为宫颈癌辅助治疗具有植物治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/23b6b06a5bc0/pharmaceuticals-16-00103-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/8dfc3c186c93/pharmaceuticals-16-00103-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/2e2fc3009c6f/pharmaceuticals-16-00103-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/23b6b06a5bc0/pharmaceuticals-16-00103-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/c6813f3afbd6/pharmaceuticals-16-00103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/439a0c8a70e8/pharmaceuticals-16-00103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/644b8c002b50/pharmaceuticals-16-00103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/77a7a68dfb59/pharmaceuticals-16-00103-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/8dfc3c186c93/pharmaceuticals-16-00103-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/2e2fc3009c6f/pharmaceuticals-16-00103-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a495/9866887/23b6b06a5bc0/pharmaceuticals-16-00103-g008.jpg

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