Department of Pathology, Medical College, Kolkata, West Bengal, India.
Middle East Afr J Ophthalmol. 2022 Nov 23;29(1):15-18. doi: 10.4103/meajo.meajo_298_21. eCollection 2022 Jan-Mar.
Meibomian carcinoma is a rare and aggressive malignant neoplasm of the eyelids. The clinical presentation often mimics benign conditions thereby making the diagnosis challenging. The aim of the study was to analyze cases of meibomian carcinoma, the specimens of which were received, in the past 2 years in the pathology department.
This retrospective observational study was undertaken for 2 years and included 9 patients of meibomian carcinoma. For each case, detailed history and clinical findings were retrieved from the hospital records. Histopathological examination was undertaken in all cases after preparing hematoxylin and eosin-stained slides from tissue blocks preserved in the department.
The mean age of the patients was 55 ± 15 years. Six (66.7%) patients were females, and the other three (33.3%) were male. Following surgery, gross examination of the specimens revealed that the mean size of the excised tumors was 2.45 ± 1.45 cm. The tumors were classified based on histopathological features according to growth pattern, cell type, and cytoarchitecture. Most cases had lobular growth pattern (5, 55.6% cases), consisted of epidermoid cells (5, 55.6% cases), and exhibited infiltrative cytoarchitecture (8, 88.9% cases).
Early diagnosis of meibomian carcinoma is important to reduce mortality from the aggressive tumor. The knowledge of clinicopathological aspects of the tumors that were biopsied in the department of pathology in the past 2 years will help in diagnosis and management of such tumors in future.
睑板腺癌是一种罕见且侵袭性的眼睑恶性肿瘤。其临床表现常类似于良性病变，因此诊断具有挑战性。本研究旨在分析过去 2 年内病理科送检的睑板腺癌病例。
本回顾性观察性研究历时 2 年，共纳入 9 例睑板腺癌患者。对每例患者，均从医院病历中检索详细的病史和临床发现。对所有病例均进行组织学检查，用科室保存的组织块制备苏木精-伊红染色切片。
患者的平均年龄为 55 ± 15 岁。其中 6 例（66.7%）为女性，3 例（33.3%）为男性。手术后，标本大体检查显示切除肿瘤的平均大小为 2.45 ± 1.45cm。根据生长模式、细胞类型和细胞结构对肿瘤进行分类。大多数病例具有小叶状生长模式（5 例，55.6%病例），由表皮样细胞组成（5 例，55.6%病例），并表现出浸润性细胞结构（8 例，88.9%病例）。
早期诊断睑板腺癌对于降低这种侵袭性肿瘤的死亡率非常重要。了解过去 2 年内病理科活检的肿瘤的临床病理特征，将有助于未来此类肿瘤的诊断和治疗。
