Császár-Nagy N, Bókkon I
National University of Public Services, Budapest, Hungary.
Psychosomatic Outpatient Clinics, Budapest, Hungary.
Heliyon. 2022 Dec 30;9(1):e12751. doi: 10.1016/j.heliyon.2022.e12751. eCollection 2023 Jan.
The association between irritable bowel syndrome (IBS) and psychiatric and mood disorders may be more fundamental than was previously believed. Prenatal, perinatal, postnatal, and early-age conditions can have a key role in the development of IBS. Subthreshold mental disorders (SMDs) could also be a significant source of countless diverse diseases and may be a cause of IBS development. We hypothesize that stress-induced implicit memories may persist throughout life by epigenetic processes in the enteric nervous system (ENS). These stress-induced implicit memories may play an essential role in the emergence and maintenance of IBS. In recent decades, numerous studies have proven that hypnosis can improve the primary symptoms of IBS and also reduce noncolonic symptoms such as anxiety and depression and improve quality of life and cognitive function. These significant beneficial effects of hypnosis on IBS may be because hypnosis allows access to unconscious brain processes.
肠易激综合征（IBS）与精神和情绪障碍之间的关联可能比之前认为的更为根本。产前、围产期、产后及幼年时期的状况在IBS的发展中可能起关键作用。阈下精神障碍（SMDs）也可能是无数种不同疾病的重要根源，并且可能是IBS发展的一个原因。我们推测，应激诱导的内隐记忆可能通过肠神经系统（ENS）中的表观遗传过程终生持续存在。这些应激诱导的内隐记忆可能在IBS的出现和维持中起重要作用。近几十年来，大量研究已证明，催眠可以改善IBS的主要症状，还能减轻焦虑和抑郁等非结肠症状，并改善生活质量和认知功能。催眠对IBS的这些显著有益效果可能是因为催眠能够触及大脑的无意识过程。
