Core Technology Laboratories, Asahi Quality & Innovations Ltd., 1-1-21, Midori, Moriya, Ibaraki 302-0106, Japan.
Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka-shi, Yamagata 997-0052, Japan.
Sci Adv. 2023 Jan 25;9(4):eadd2120. doi: 10.1126/sciadv.add2120.
Although gut microbiota has been linked to exercise, whether alterations in the abundance of specific bacteria improve exercise performance remains ambiguous. In a cross-sectional study involving 25 male long-distance runners, we found a correlation between abundance in feces and the 3000-m race time. In addition, we administered flaxseed lignan or α-cyclodextrin as a test tablet to healthy, active males who regularly exercised in a randomized, double-blind, placebo-controlled study to increase in the gut (UMIN000033748). The results indicated that α-cyclodextrin supplementation improved human endurance exercise performance. Moreover, administration in mice increased swimming time to exhaustion, cecal short-chain fatty acid concentrations, and the gene expression of enzymes associated with gluconeogenesis in the liver while decreasing hepatic glycogen content. These findings indicate that enhances endurance exercise performance, which may be mediated by facilitating hepatic endogenous glucose production.
虽然肠道微生物群与运动有关，但特定细菌丰度的改变是否能提高运动表现仍不清楚。在一项涉及 25 名男性长跑运动员的横断面研究中，我们发现粪便丰度与 3000 米比赛时间之间存在相关性。此外，我们在一项随机、双盲、安慰剂对照的研究中，给经常运动的健康男性服用亚麻籽木脂素或 α-环糊精作为试验片，以增加肠道中的 （UMIN000033748）。结果表明，α-环糊精补充剂可提高人体耐力运动表现。此外，在小鼠中给药可增加游泳至力竭的时间、盲肠短链脂肪酸浓度以及与肝脏糖异生相关的酶的基因表达，同时降低肝糖原含量。这些发现表明 可增强耐力运动表现，这可能是通过促进肝脏内源性葡萄糖生成来介导的。
