Jain Heena, Chahal Shiwani, Singh Inderjeet, Sain Satish Kumar, Siwach Priyanka
Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, Haryana, 125055, India.
Central Institute of Cotton Research, Regional Station, Sirsa, Haryana, 125055, India.
Mol Biol Rep. 2023 Apr;50(4):3835-3848. doi: 10.1007/s11033-023-08266-y. Epub 2023 Jan 26.
Geminiviruses are among the most threatening emerging plant viruses, accountable for a huge loss to agricultural production worldwide. These viruses have been responsible for some serious outbreaks during the last few decades across different parts of the world. Sincere efforts have been made to regulate the disease incidence by incorporating a multi-dimensional approach, and this process has been facilitated greatly by the advent of molecular techniques. But, the mixed infection due to the polyphagous nature of vectors results in viral recombination followed by the emergence of novel viral strains which thus renders the existing mitigation strategies ineffective. Hence, a multifaceted insight into the molecular mechanism of the disease is really needed to understand the regulatory points; much has been done in this direction during the last few years. The present review aims to explore all the latest developments made so far and to organize the information in a comprehensive manner so that some novel hypotheses for controlling the disease may be generated.
Starting with the background information, diverse genera of geminiviruses are listed along with their pathological and economic impacts. A comprehensive and detailed mechanism of infection is elaborated to study the interactions between vector, host, and virus at different stages in the life cycle of geminiviruses. Finally, an effort isalso made to analyze the progress made at the molecular level for the development of various mitigation strategies and suggest more effective and better approaches for controlling the disease.
The study has provided a thorough understanding of molecular mechanism of geminivirus infection.
双生病毒是最具威胁的新兴植物病毒之一，给全球农业生产造成了巨大损失。在过去几十年里，这些病毒在世界各地引发了一些严重的疫情。人们已通过采用多维度方法，真诚努力地控制疾病发生率，分子技术的出现极大地推动了这一进程。但是，由于传毒介体具有多食性，混合感染会导致病毒重组，进而产生新的病毒株，这使得现有的防控策略失效。因此，确实需要从多方面深入了解该疾病的分子机制，以明确调控关键点；在过去几年里，这方面已经取得了很多进展。本综述旨在探讨迄今为止所有的最新进展，并全面整理相关信息，以便提出一些控制该疾病的新假设。
从背景信息入手，列出了双生病毒的不同属及其病理和经济影响。详细阐述了双生病毒感染的综合机制，以研究传毒介体、寄主和病毒在双生病毒生命周期不同阶段的相互作用。最后，还努力分析了在开发各种防控策略方面在分子水平上取得的进展，并提出更有效、更好的控制该疾病的方法。
该研究全面深入地了解了双生病毒感染的分子机制。
