Lehmkuhl Sören, Emondts Meike, Schubert Lukas, Spannring Peter, Klankermayer Jürgen, Blümich Bernhard, Schleker P Philipp M
ITMC.MC, RWTH Aachen University, Worringerweg 2, 52074, Aachen, Germany.
Max-Planck-Institut für Chemische Energiekonversion, Stiftstr. 34-36, 45470, Mülheim an der Ruhr, Germany.
Chemphyschem. 2017 Sep 20;18(18):2426-2429. doi: 10.1002/cphc.201700750. Epub 2017 Aug 15.
Studies of water-based systems are of fundamental interest for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) as water is the most abundant and important medium for global living. Hence, increasing the polarization of water and dissolved compounds is particularly attractive for biomedical applications such as investigations of intermolecular interactions and metabolite structures as well as for imaging purposes. In this work, we show a new approach based on para enriched hydrogen (p-H ) that enables the hyperpolarization of bulk water if a suitable catalytic system is employed. The results indicate that the polarization is transferred by a new exchange mechanism.
对于核磁共振（NMR）和磁共振成像（MRI）而言，基于水的体系研究具有根本重要性，因为水是全球生命中最丰富且最重要的介质。因此，提高水和溶解化合物的极化度对于生物医学应用极具吸引力，比如用于分子间相互作用和代谢物结构的研究以及成像目的。在这项工作中，我们展示了一种基于富含仲氢（p-H₂）的新方法，若采用合适的催化体系，该方法能够实现大量水的超极化。结果表明，极化是通过一种新的交换机制进行传递的。
