Oyarzun Javiera P, Kuntz Thomas M, Stussi Yoann, Karaman Olivia T, Vranos Sophia, Callaghan Bridget L, Huttenhower Curtis, LeDoux Joseph E, Phelps Elizabeth A
Department of Psychology, Harvard University, Cambridge, MA 02138, USA.
Center for Neural Science and Department of Psychology, New York University, New York NY, 10003, USA.
PNAS Nexus. 2022 Dec 2;1(5):pgac271. doi: 10.1093/pnasnexus/pgac271. eCollection 2022 Nov.
The ability to learn about threat and safety is critical for survival. Studies in rodent models have shown that the gut microbiota can modulate such behaviors. In humans, evidence showing an association with threat or extinction learning is lacking. Here, we tested whether individual variability in threat and extinction learning was related to gut microbiota composition in healthy adults. We found that threat, but not extinction learning, varies with individuals' microbiome composition. Our results provide evidence that the gut microbiota is associated with excitatory threat learning across species.
了解威胁和安全的能力对生存至关重要。对啮齿动物模型的研究表明，肠道微生物群可调节此类行为。在人类中，缺乏显示与威胁或消退学习相关的证据。在此，我们测试了健康成年人中威胁和消退学习的个体差异是否与肠道微生物群组成有关。我们发现，威胁学习而非消退学习随个体的微生物组组成而变化。我们的结果提供了证据，表明肠道微生物群与跨物种的兴奋性威胁学习相关。
