Wingo Brooks C, Rinker John R, Green Kathryn, Peterson Courtney M
Department of Occupational Therapy, University of Alabama at Birmingham, Birmingham, AL, United States.
Department of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Front Neurol. 2023 Jan 12;13:1087126. doi: 10.3389/fneur.2022.1087126. eCollection 2022.
Intermittent fasting (IF) has become a popular dietary pattern for adults with multiple sclerosis (MS), and initial studies in animal models and human trials indicate promising results for improving symptoms and slowing disease progression. Most studies published to date have focused on alternate day fasting or fasting mimicking diets including a 5:2 pattern, in which participants greatly restrict calorie intake on two non-consecutive days and eat regularly on other days; however, time restricted eating (TRE) may be equally effective for improving symptoms and may lead to better long term adherence due to its focus only on the time of day in which calories are consumed with no restriction on number of calories or types of food consumed.
The purpose of this pilot study was to determine the feasibility and acceptability of a TRE intervention in adults with relapsing remitting MS (RRMS). Participants ( = 12) were instructed to eat all food within an 8-h window every day and fast the remaining 16 h for 8 weeks.
The eating pattern was determined to be feasible based on retention rates ( = 11; 92%) and acceptable based on participant feedback.
Exploratory results of changes in cognition, pain, and fatigue, indicate that further study of TRE in this population is warranted.
https://clinicaltrials.gov/ct2/show/NCT04389970; NCT04389970.
间歇性禁食（IF）已成为成年多发性硬化症（MS）患者中一种流行的饮食模式，动物模型和人体试验的初步研究表明，在改善症状和减缓疾病进展方面有令人期待的结果。迄今为止发表的大多数研究都集中在隔日禁食或模拟禁食饮食，包括5:2模式，即参与者在两个非连续日大幅限制热量摄入，其他日子正常饮食；然而，限时进食（TRE）在改善症状方面可能同样有效，并且由于其仅关注热量摄入的时间，而不限制热量的数量或所摄入食物的种类，可能会导致更好的长期依从性。
这项初步研究的目的是确定TRE干预对复发缓解型MS（RRMS）成年患者的可行性和可接受性。参与者（n = 12）被指示每天在8小时内吃完所有食物，并在其余16小时禁食，持续8周。
根据留存率（n = 11；92%），确定这种饮食模式是可行的，并且根据参与者的反馈，它是可接受的。
关于认知、疼痛和疲劳变化的探索性结果表明，有必要对该人群的TRE进行进一步研究。
https://clinicaltrials.gov/ct2/show/NCT04389970；NCT04389970。
