Ma Teng-Chi, Zhou Jing, Wang Chen-Xi, Lin Zhi-Zhi, Gao Feng
Department of Cardiology, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi, China.
Front Nutr. 2023 Jan 11;9:904745. doi: 10.3389/fnut.2022.904745. eCollection 2022.
The Healthy Eating Index (HEI) is a dietary index developed by the United States Department of Agriculture (USDA) to determine whether a diet adheres to US dietary guidelines. Soluble Klotho (S-Klotho) is a protein with essential anti-aging properties. However, whether HEI is linked to S-Klotho plasma levels is still debatable. This study aimed to assess the association between HEI-2015 and S-Klotho in middle-to-older aged adults in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016.
The study included 8456 middle-to-older aged (40-79 years old) participants. Multivariate regression models were used to estimate the correlation between HEI-2015 and S-Klotho concentrations. General additive models and two-piece-wise regression models were used to investigate the possible non-linear relationships between HEI-2015 and S-Klotho concentrations. Moreover, a stratified analysis of potential influencing factors was performed.
A positive correlation was observed between HEI-2015 and S-Klotho plasma levels (β = 0.74, 95% CI: 0.21, 1.27, = 0.0067). According to the two-piece-wise regression, the turning point of HEI-2015 was 45.15. When the range of HEI-2015 was from 0 to 45.15, the relationship between HEI and S-Klotho was insignificant (β = -0.87, 95% CI: -2.47, 0.73, = 0.2858). However, when the range of HEI-2015 was from 45.15 to 100, HEI-2015 increased by 1 unit, the S-Klotho increased by 1.30 pg/ml (β = 1.30, 95% CI: 0.55, 2.05, = 0.0007), suggesting a dose-response relationship. Furthermore, the stratified analysis showed that the association between HEI-2015 and S-Klotho concentrations was more significant in people with normal body mass index (P-interaction = 0.0161).
There is a dose-response relationship between the HEI-2015 and S-Klotho in the middle-to-older aged adults. This relationship suggests that adherence to healthy dietary patterns may benefit the prevention of aging and health maintenance. The underlying mechanisms require further investigation.
健康饮食指数（HEI）是美国农业部（USDA）制定的一种饮食指数，用于确定一种饮食是否符合美国饮食指南。可溶性klotho（S-Klotho）是一种具有重要抗衰老特性的蛋白质。然而，HEI是否与S-Klotho血浆水平相关仍存在争议。本研究旨在评估2007年至2016年美国国家健康与营养检查调查（NHANES）中中老年成年人HEI-2015与S-Klotho之间的关联。
该研究纳入了8456名中老年（40-79岁）参与者。使用多元回归模型估计HEI-2015与S-Klotho浓度之间的相关性。使用一般加性模型和两段式回归模型研究HEI-2015与S-Klotho浓度之间可能的非线性关系。此外，对潜在影响因素进行了分层分析。
观察到HEI-2015与S-Klotho血浆水平呈正相关（β = 0.74，95%CI：0.21，1.27，P = 0.0067）。根据两段式回归，HEI-2015的转折点为45.15。当HEI-2015的范围为0至45.15时，HEI与S-Klotho之间的关系不显著（β = -0.87，95%CI：-2.47，0.73，P = 0.2858）。然而，当HEI-2015的范围为45.15至100时，HEI-2015每增加1个单位，S-Klotho增加1.30 pg/ml（β = 1.30，95%CI：0.55，2.05，P = 0.0007），表明存在剂量反应关系。此外，分层分析表明，在体重指数正常的人群中，HEI-2015与S-Klotho浓度之间的关联更为显著（P交互作用 = 0.0161）。
中老年成年人中HEI-2015与S-Klotho之间存在剂量反应关系。这种关系表明，坚持健康的饮食模式可能有利于预防衰老和维持健康。其潜在机制需要进一步研究。
