环状 RNA 疫苗的研究进展。
Research progress on circular RNA vaccines.
机构信息
Division of Hepatitis and Enterovirus Vaccines, National Institutes for Food and Drug Control, Beijing, China.
NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, Beijing, China.
出版信息
Front Immunol. 2023 Jan 12;13:1091797. doi: 10.3389/fimmu.2022.1091797. eCollection 2022.
Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the metabolism and biological functions of circRNAs, and research progress and production process of circRNA vaccines. Further, considerations regarding the quality control of circRNA vaccines are highlighted herein, and the main challenges and problem-solving strategies in circRNA vaccine development and quality control are outlined to provide a reference for circRNA vaccine-related research.
由于线性 mRNA 冠状病毒病 2019（COVID-19）疫苗的成功，全球生物制药公司和研究团队都试图开发更稳定的环状 RNA（circRNA）疫苗，并取得了一些初步成果。本综述旨在总结环状 RNA 研究的关键发现和重要进展、环状 RNA 的代谢和生物学功能，以及环状 RNA 疫苗的研究进展和生产工艺。此外，本文还强调了环状 RNA 疫苗的质量控制考虑因素，并概述了环状 RNA 疫苗开发和质量控制中面临的主要挑战和解决策略，为环状 RNA 疫苗相关研究提供参考。
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