Han Bingchen, Shen Lidan, Xie Hanbing, Huang Qi, Zhao Dan, Huang Xianju, Chen Xiao, Li Jun
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430079, China.
Ethnopharmacology Level 3 Laboratory, National Administration of Traditional Chinese Medicine, Wuhan 430079, China.
ACS Omega. 2023 Jan 10;8(3):3176-3183. doi: 10.1021/acsomega.2c06600. eCollection 2023 Jan 24.
As novel nanomaterials developed gradually with nanotechnology, carbon dots have been widely applied in medical applications, including disease treatment, drug delivery, antibacterial applications, and phototherapy. Based on the similar process between Chinese medicinal materials for hemostasis and modern carbon dots, this paper reports the preparation of four luminescent carbon dots with Chinese medicinal materials (plants and animals) as carbon sources and the investigation on their hemostatic effects in vitro and in rat bleeding models. It is found that the four studied carbon dots exhibit similar hemostatic effects and hemostatic mechanisms through impacting both endogenous and exogenous coagulation pathways. In addition, these carbon dots all exhibit anti-inflammatory effects and good biocompatibility, ensuring their potential in pretraumatic fields. This work provides a new perspective for hemostatic carbon dots prepared using carbonized natural plants and animals and new ideas for the research of new hemostatic materials.
随着纳米技术的不断发展，新型纳米材料逐渐涌现，碳点已广泛应用于医学领域，包括疾病治疗、药物递送、抗菌应用和光疗。基于中药止血材料与现代碳点之间的相似制备过程，本文报道了以中药材（植物和动物）为碳源制备四种发光碳点，并对其体外及大鼠出血模型中的止血效果进行研究。研究发现，这四种碳点通过影响内源性和外源性凝血途径表现出相似的止血效果和止血机制。此外，这些碳点均具有抗炎作用和良好的生物相容性，确保了它们在创伤前领域的应用潜力。这项工作为利用碳化天然植物和动物制备止血碳点提供了新的视角，也为新型止血材料的研究提供了新思路。
