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2018 年布隆迪和 2019 年马拉维家猪暴发疫情的非洲猪瘟病毒全基因组分析。

Complete genome analysis of African swine fever virus responsible for outbreaks in domestic pigs in 2018 in Burundi and 2019 in Malawi.

机构信息

SACIDS Africa Centre of Excellence for Infectious Diseases, SACIDS Foundation for One Health, Sokoine University of Agriculture, PO Box 3297, Morogoro, Tanzania.

Department of Veterinary Microbiology, Parasitology and Biotechnology, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, PO Box 3019, Morogoro, Tanzania.

出版信息

Trop Anim Health Prod. 2021 Aug 17;53(4):438. doi: 10.1007/s11250-021-02877-y.

DOI:10.1007/s11250-021-02877-y
PMID:34402985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8368048/
Abstract

Several African swine fever (ASF) outbreaks in domestic pigs have been reported in Burundi and Malawi and whole-genome sequences of circulating outbreak viruses in these countries are limited. In the present study, complete genome sequences of ASF viruses (ASFV) that caused the 2018 outbreak in Burundi (BUR/18/Rutana) and the 2019 outbreak in Malawi (MAL/19/Karonga) were produced using Illumina next-generation sequencing (NGS) platform and compared with other previously described ASFV complete genomes. The complete nucleotide sequences of BUR/18/Rutana and MAL/19/Karonga were 176,564 and 183,325 base pairs long with GC content of 38.62 and 38.48%, respectively. The MAL/19/Karonga virus had a total of 186 open reading frames (ORFs) while the BUR/18/Rutana strain had 151 ORFs. After comparative genomic analysis, the MAL/19/Karonga virus showed greater than 99% nucleotide identity with other complete nucleotides sequences of p72 genotype II viruses previously described in Tanzania, Europe and Asia including the Georgia 2007/1 isolate. The Burundian ASFV BUR/18/Rutana exhibited 98.95 to 99.34% nucleotide identity with genotype X ASFV previously described in Kenya and in Democratic Republic of the Congo (DRC). The serotyping results classified the BUR/18/Rutana and MAL/19/Karonga ASFV strains in serogroups 7 and 8, respectively. The results of this study provide insight into the genetic structure and antigenic diversity of ASFV strains circulating in Burundi and Malawi. This is important in order to understand the transmission dynamics and genetic evolution of ASFV in eastern Africa, with an ultimate goal of designing an efficient risk management strategy against ASF transboundary spread.

摘要

布隆迪和马拉维国内猪群中暴发了几起非洲猪瘟（ASF）疫情，但这两个国家流行病毒的全基因组序列有限。在本研究中，使用 Illumina 下一代测序（NGS）平台生成了导致布隆迪 2018 年疫情（BUR/18/Rutana）和马拉维 2019 年疫情（MAL/19/Karonga）的 ASF 病毒（ASFV）的完整基因组序列，并与其他先前描述的 ASFV 完整基因组进行了比较。BUR/18/Rutana 和 MAL/19/Karonga 的完整核苷酸序列分别为 176564 和 183325 个碱基，GC 含量分别为 38.62%和 38.48%。MAL/19/Karonga 病毒共有 186 个开放阅读框（ORF），而 BUR/18/Rutana 株有 151 个 ORF。经过比较基因组分析，MAL/19/Karonga 病毒与坦桑尼亚、欧洲和亚洲先前描述的其他 p72 基因型 II 病毒的完整核苷酸序列具有大于 99%的核苷酸同一性，包括格鲁吉亚 2007/1 分离株。布隆迪 ASFV BUR/18/Rutana 与先前在肯尼亚和刚果民主共和国（DRC）描述的基因型 X ASFV 表现出 98.95%至 99.34%的核苷酸同一性。血清分型结果将 BUR/18/Rutana 和 MAL/19/Karonga ASFV 株分别归类为 7 血清群和 8 血清群。本研究结果为了解布隆迪和马拉维流行的 ASFV 株的遗传结构和抗原多样性提供了线索。这对于了解东非 ASF 的传播动态和遗传进化非常重要，最终目标是制定有效的非洲猪瘟跨境传播风险管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/8370919/18bb913859bd/11250_2021_2877_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/8370919/7f01d4650eb5/11250_2021_2877_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/8370919/404a35cc60c4/11250_2021_2877_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/8370919/18bb913859bd/11250_2021_2877_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/8370919/7f01d4650eb5/11250_2021_2877_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/8370919/404a35cc60c4/11250_2021_2877_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ec/8370919/18bb913859bd/11250_2021_2877_Fig3_HTML.jpg

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