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Factor H autoantibodies contribute to complement dysregulation in multisystem inflammatory syndrome in children (MIS-C).

作者信息

Zerra Patricia E, Stowell Jennifer, Verkerke Hans, McCoy James, Jones Jayre, Graciaa Sara, Lu Austin, Hussaini Laila, Anderson Evan J, Rostad Christina A, Stowell Sean R, Chonat Satheesh

机构信息

Center for Transfusion Medicine and Cellular Therapies, Department of Laboratory Medicine and Pathology, Emory University, Atlanta, Georgia, USA.

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, Georgia, USA.

出版信息

Am J Hematol. 2023 May;98(5):E98-E101. doi: 10.1002/ajh.26868. Epub 2023 Feb 13.

DOI:10.1002/ajh.26868
PMID:36715424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10089943/
Abstract
摘要

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本文引用的文献

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TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C.TIM3+ TRBV11-2 T 细胞和 IFNγ 特征可在巡弋的单核细胞和 CD16+NK 细胞中对 MIS-C 进行描绘。
J Exp Med. 2022 Feb 7;219(2). doi: 10.1084/jem.20211381. Epub 2021 Dec 16.
2
Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome.重症新型冠状病毒肺炎急性呼吸窘迫综合征中的补体抑制
Front Pediatr. 2020 Dec 29;8:616731. doi: 10.3389/fped.2020.616731. eCollection 2020.
3
Complement C5 inhibition in patients with COVID-19 - a promising target?新冠病毒肺炎患者中补体C5抑制——一个有前景的靶点？
Haematologica. 2020 Dec 1;105(12):2847-2850. doi: 10.3324/haematol.2020.260117.
4
COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City.COVID-19 肺部病理学：来自意大利和纽约市的多机构尸检队列研究。
Mod Pathol. 2020 Nov;33(11):2156-2168. doi: 10.1038/s41379-020-00661-1. Epub 2020 Sep 2.
5
Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C).儿童多系统炎症综合征（MIS-C）中 SARS-CoV-2 血清学的定量分析。
Pediatrics. 2020 Dec;146(6). doi: 10.1542/peds.2020-018242. Epub 2020 Sep 2.
6
Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition.SARS-CoV-2 刺突蛋白直接激活替代补体途径被因子 D 抑制所阻断。
Blood. 2020 Oct 29;136(18):2080-2089. doi: 10.1182/blood.2020008248.
7
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.严重 COVID-19 感染发病机制中的补体相关微血管损伤和血栓形成：五例报告。
Transl Res. 2020 Jun;220:1-13. doi: 10.1016/j.trsl.2020.04.007. Epub 2020 Apr 15.
8
Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland.因子 H 自身抗体与英国和爱尔兰儿童的非典型溶血性尿毒症综合征有关。
Kidney Int. 2017 Nov;92(5):1261-1271. doi: 10.1016/j.kint.2017.04.028. Epub 2017 Jul 24.
9
Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children.促发血浆置换和免疫抑制治疗可改善儿童抗因子 H 自身抗体相关性溶血尿毒综合征的预后。
Kidney Int. 2014 May;85(5):1151-60. doi: 10.1038/ki.2013.373. Epub 2013 Oct 2.
10
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome.抗因子H自身抗体在溶血尿毒综合征中阻断因子H的C端识别功能。
Blood. 2007 Sep 1;110(5):1516-8. doi: 10.1182/blood-2007-02-071472. Epub 2007 May 10.