Persky V W, Kempthorne-Rawson J, Shekelle R B
Epidemiology/Biometry Program, School of Public Health, University of Illinois, Chicago 60680.
Psychosom Med. 1987 Sep-Oct;49(5):435-49. doi: 10.1097/00006842-198709000-00001.
Psychologic depression as measured by the Minnesota Multiphasic Personality Inventory (MMPI) in a cohort of 2018 middle-aged men employed at the Western Electric Company in 1957-1958 was positively associated with 20-year incidence and mortality from cancer. The association with incidence was apparent only during the first 10 years of follow-up, but the association with mortality was observed for the full 20 years of follow-up. The association persisted after adjustment for age, number of cigarettes smoked, alcohol intake, occupational status, family history of cancer, body mass index, and serum cholesterol. The association did not appear to be stronger for one type of cancer than another, but the power of this study to detect differences among types of cancer was limited by small numbers. However, the association did appear to be stronger with risk of fatal cancer than with total incidence. No association was noted between other variables measured by the MMPI or Cattell 16 Personality Factor Inventory and subsequent incidence or mortality from cancer. Specifically, the data did not support the hypothesis that psychologic repression, as measured by Welsh R scale in the MMPI, would be associated with risk of cancer. These results are consistent with previously reported results that have suggested that psychologic depression might promote the development and spread of malignant neoplasms.
1957年至1958年期间，对西方电气公司的2018名中年男性进行了明尼苏达多相人格调查表（MMPI）测量，结果显示心理抑郁与20年癌症发病率和死亡率呈正相关。与发病率的关联仅在随访的前10年中明显，但在整个20年的随访中都观察到了与死亡率的关联。在对年龄、吸烟数量、酒精摄入量、职业状况、癌症家族史、体重指数和血清胆固醇进行调整后，这种关联依然存在。这种关联在一种癌症类型上似乎并不比另一种更强，但由于样本数量少，本研究检测不同癌症类型之间差异的能力有限。然而，与致命癌症风险的关联似乎确实比与总发病率的关联更强。在通过MMPI或卡特尔16种人格因素量表测量的其他变量与随后的癌症发病率或死亡率之间未发现关联。具体而言，数据不支持以下假设：通过MMPI中的威尔士R量表测量的心理压抑与癌症风险相关。这些结果与先前报道的结果一致，表明心理抑郁可能促进恶性肿瘤的发生和扩散。
