Chen Chiao-Yun, Liu Yu-Hua, Muggleton Neil G
Department of Criminology, National Chung Cheng University, Minhsiung, Chiayi, Taiwan.
Institute of Cognitive Neuroscience, National Central University, Taoyuan, Taiwan.
IBRO Neurosci Rep. 2023 Jan 16;14:122-128. doi: 10.1016/j.ibneur.2023.01.001. eCollection 2023 Jun.
Drug use causes significant social and financial problems and these are exacerbated by difficulties in stopping use and subsequent maintenance of abstinence. There is also difficulty in identifying the beneficial treatment for an individual, made more problematic given the high drop-out rates in treatment programs. Here, the effects of transcranial direct current stimulation (tDCS) on the amplitude of the P300 event-related potential component, previously suggested to be indicative of successful remission, was measured in recently abstinent amphetamine users. This component was collected during a Posner cuing task which was presented to this group and to control (non-user) participants, using task cues of neutral and drug-related images. The abstinent drug users were divided into two groups, one of which received tDCS daily for five days, with the cathode over the left dorsolateral prefrontal cortex (DLPFC) and the anode over the right DLPFC, and one receiving sham stimulation over the same time period. Behavioral performance and P300 amplitudes were measured before and after the period of tDCS delivery. Control participants were tested with the same time-schedule of task presentation but without administration of tDCS. Drug users initially showed a larger cost of invalid cues on task performance compared to control (non-drug user) participants and this was reduced following delivery of tDCS. Additionally, tDCS resulted in increased amplitude of the P300 component, significantly so for neutral cues, with the resulting pattern being more similar to that of the non-users. This provides a good basis for further investigation of both the utility of tDCS in modulation of cognition in addict groups, and to investigate the effects of modulating the P300 component on remission rates, a relationship that seems to be the case for this measure without use of tDCS modulation. Importantly, this study also provides a further addiction group showing P300 amplitude modulation as a result of tDCS administration.
药物使用会引发严重的社会和经济问题，而戒毒困难以及后续保持戒断状态会使这些问题进一步恶化。此外，确定针对个体的有效治疗方法也存在困难，鉴于治疗项目的高辍学率，这一问题变得更加棘手。在此，研究人员对近期戒毒的苯丙胺使用者测量了经颅直流电刺激（tDCS）对P300事件相关电位成分波幅的影响，此前有研究表明该成分可指示成功戒毒。该成分是在向这组使用者以及对照组（非使用者）参与者呈现的Posner线索任务中收集的，使用的任务线索包括中性和与毒品相关的图像。戒毒者被分为两组，其中一组连续五天每天接受tDCS治疗，阴极置于左侧背外侧前额叶皮层（DLPFC），阳极置于右侧DLPFC，另一组在同一时期接受假刺激。在tDCS治疗前后测量行为表现和P300波幅。对照组参与者按照相同的任务呈现时间安排进行测试，但不接受tDCS治疗。与对照组（非吸毒者）参与者相比，吸毒者最初在任务表现上因无效线索而付出的代价更大，而在接受tDCS治疗后这一情况有所减轻。此外，tDCS导致P300成分的波幅增加，对于中性线索而言增加显著，最终模式与非使用者的模式更为相似。这为进一步研究tDCS在调节成瘾群体认知方面的效用，以及研究调节P300成分对戒毒率的影响提供了良好基础，这种关系在未使用tDCS调节的情况下似乎也是如此。重要的是，这项研究还提供了另一个成瘾群体，该群体因接受tDCS治疗而出现P300波幅调制。
