Sahoo Jyotiranjan, Mohanty Sambedana, Kundu Arijit, Epari Venkatarao
Community Medicine, Siksha 'O' Anusandhan Deemed to be University Institute of Medical Sciences and SUM Hospital, Bhubaneswar, IND.
Community Medicine, Shri Ramkrishna Institute of Medical Science and Sanaka Hospitals, Bhubaneswar, IND.
Cureus. 2022 Dec 29;14(12):e33074. doi: 10.7759/cureus.33074. eCollection 2022 Dec.
Type 2 diabetes mellitus is a major public health problem. Adherence to anti-diabetic medications improves glycaemic control, which in turn prevents complications as well as reduces out-of-pocket expenditure. The World Health Organization highlights that the impact of interventions directed to improve adherence has far greater implications than specific medical interventions. There are several factors that contribute to poor adherence. Not many studies have been conducted to explore adherence to diabetes medications in eastern India.
To measure medication adherence among patients suffering from diabetes. To determine the various risk factors influencing adherence to medication. To find out the association of health-related quality of life with adherence to medication.
A hospital-based cross-sectional study was conducted in the outpatient Department of General Medicine and Endocrinology of a tertiary care hospital in eastern India from January to March 2020. Adult subjects, who were diagnosed with type 2 diabetes mellitus for at least six months, were interviewed using a pretested, structured questionnaire containing 8-item Morisky Medication Adherence Scale (MMAS-8) to determine adherence to diabetic medications. Data were analysed in SPSS version 27 (IBM Corp., Armonk, NY, USA).
The mean age of the 331 participants interviewed was 53.40 (SD 11.0) years and the majority were males (57.1%). Medication adherence of 34.14% (n=113) was found among the subjects. Having any comorbidity, positive family history of diabetes and the habit of current alcohol intake increased the odds of poor adherence by 3.26 times, 1.88 times, and 2.35 times respectively in binary logistic regression analysis. Those following a diabetic diet had a protective effect, decreasing poor medication adherence by 79.6%. Poor medication adherence increased by 1.077 times with every one-day increase in unhealthy days.
The medication adherence was 34.14% and as compared to other similar studies medication adherence in the study population was poor and was associated with unhealthy days.
2型糖尿病是一个重大的公共卫生问题。坚持服用抗糖尿病药物可改善血糖控制，进而预防并发症并减少自付费用。世界卫生组织强调，旨在提高依从性的干预措施的影响比特定的医疗干预措施具有更深远的意义。导致依从性差的因素有很多。在印度东部，针对糖尿病药物依从性的研究并不多。
测量糖尿病患者的药物依从性。确定影响药物依从性的各种风险因素。找出健康相关生活质量与药物依从性之间的关联。
2020年1月至3月，在印度东部一家三级护理医院的普通内科和内分泌科门诊进行了一项基于医院的横断面研究。对被诊断为2型糖尿病至少六个月的成年受试者，使用一份经过预测试的包含8项Morisky药物依从性量表（MMAS-8）的结构化问卷进行访谈，以确定糖尿病药物的依从性。数据在SPSS 27版（美国纽约州阿蒙克市IBM公司）中进行分析。
接受访谈的331名参与者的平均年龄为53.40（标准差11.0）岁，大多数为男性（57.1%）。在这些受试者中，发现药物依从性为34.14%（n = 113）。在二元逻辑回归分析中，患有任何合并症、有糖尿病家族史阳性以及当前有饮酒习惯分别使依从性差的几率增加3.26倍、1.88倍和2.35倍。遵循糖尿病饮食有保护作用，可使药物依从性差的情况减少79.6%。不健康天数每增加一天，药物依从性差的情况就增加1.077倍。
药物依从性为34.14%，与其他类似研究相比，该研究人群中的药物依从性较差，且与不健康天数有关。
