Song Yanjun, Chang Zhen'ge, Jia Lei, Song Weihua, Wang Hongjian, Dong Qiuting, Dou Kefei
State Key Laboratory of Cardiovascular Disease, Beijing, China.
Cardiometabolic Medicine Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167A Beilishi Road, Xi Cheng District, Beijing 100037, China.
Food Funct. 2023 Feb 6;14(3):1740-1749. doi: 10.1039/d2fo03066g.
The Mediterranean-DASH intervention for neurodegenerative delay (MIND) diet has been evaluated as a brain-protective diet pattern that contributes to better cognitive performance and attenuates dementia. Cardioprotective effects of the MIND diet have been demonstrated in the primary prevention of atherosclerotic cardiovascular disease (ASCVD), however, there is no exploration in patients with ASCVD. In this prospective cohort study, 943 patients with ASCVD or stroke from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2006 were enrolled and divided into three groups according to the MIND diet scores (≤7.0, 7.5-8.0, and ≥8.5). Compared with patients with low MIND diet scores (≤7.0), patients with better adherence to the MIND diet presented a significantly lower risk of all-cause and CV death, as results showed that the hazard ratio [HR] and 95% confidence interval [CI] were 1.09 (0.78, 1.52) in the group of 7.5-8.0, 0.66 (0.50, 0.87) in the group of ≥8.5 for all-cause mortality ( trend = 0.002); 0.70 (0.42, 1.17) in the group of 7.5-8.0 and 0.52 (0.35, 0.75) in the group of ≥8.5 for CV mortality ( for trend < 0.001). Besides, per one-score increase in the MIND diet score was associated with a 10% (HR = 0.90, 95% CI: 0.82, 0.99) lower risk of all-cause mortality and a 16% (HR = 0.84, 95% CI: 0.73, 0.97) lower risk of CV mortality in these patients. In conclusion, this study, for the first time, revealed that better adherence to the MIND diet was associated with improved outcomes in patients with ASCVD.
地中海-得舒饮食延缓神经退行性变（MIND）饮食已被评估为一种具有脑保护作用的饮食模式，有助于提高认知能力并减轻痴呆。MIND饮食对心血管的保护作用已在动脉粥样硬化性心血管疾病（ASCVD）的一级预防中得到证实，然而，尚未在ASCVD患者中进行探索。在这项前瞻性队列研究中，纳入了943名2003年至2006年美国国家健康与营养检查调查（NHANES）中的ASCVD或中风患者，并根据MIND饮食评分（≤7.0、7.5-8.0和≥8.5）分为三组。与MIND饮食评分低（≤7.0）的患者相比，更好地坚持MIND饮食的患者全因死亡和心血管死亡风险显著降低，结果显示，在7.5-8.0组中，全因死亡率的风险比[HR]和95%置信区间[CI]为1.09（0.78，1.52），≥8.5组为0.66（0.50，0.87）（趋势=0.002）；在7.5-8.0组中，心血管死亡率的HR为0.70（0.42，1.17），≥8.5组为0.52（0.35，0.75）（趋势<0.001）。此外，在这些患者中，MIND饮食评分每增加一分，全因死亡率风险降低10%（HR=0.90，95%CI：0.82，0.99），心血管死亡率风险降低16%（HR=0.84，95%CI：0.73，0.97）。总之，本研究首次揭示，更好地坚持MIND饮食与ASCVD患者的预后改善相关。
