Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical Microbiology, Karolinska university Hospital, Stockholm, Sweden.
Acta Paediatr. 2023 May;112(5):1049-1055. doi: 10.1111/apa.16699. Epub 2023 Feb 15.
Human bocavirus 1 (HBoV1) has been associated with respiratory tract infections in children. We aimed at retrospectively describing patient characteristics, seasonality, pre-existing medical conditions, codetections, clinical manifestations and complications of HBoV1 infection in relation to viral load in the child population in Stockholm, with the overarching aim of elucidating the clinical significance of HBoV1.
We included all hospitalised children 0-17 years testing positive for HBoV1 by real-time polymerase chain reaction on nasopharyngeal aspirates 1 July 2008-30 June 2019. Patients with HBoV1 single detection, high viral load expressed as an HBoV1-DNA cycle threshold (Ct) < 25, or both, were separately analysed. We retrieved information on pre-existing conditions and clinical course from the medical records.
We found 768 episodes in 727 children, 496 (64.6%) male and 441 (60.7%) previously healthy. The median age was 17.6 months. Most (476/768, 62.0%) episodes occurred during December-March. HBoV1 was in 549 episodes (71.5%) codetected with other viruses. Ct < 25 was independently associated with young age, single detection of HBoV1 and presentation early in the epidemic season. We saw few differences in clinical manifestations between the subgroups.
Our findings are consistent with primary HBoV1 infection causing mild-to-severe respiratory tract manifestations in young children.
人博卡病毒 1 型（HBoV1）与儿童呼吸道感染有关。我们旨在回顾性描述斯德哥尔摩儿童人群中 HBoV1 感染的患者特征、季节性、预先存在的医疗条件、合并感染、临床表现和并发症与病毒载量的关系，主要目的是阐明 HBoV1 的临床意义。
我们纳入了所有在 2008 年 7 月 1 日至 2019 年 6 月 30 日期间通过实时聚合酶链反应检测鼻咽抽吸物中 HBoV1 呈阳性的住院儿童。分别分析了 HBoV1 单次检测、高病毒载量（以 HBoV1-DNA 循环阈值（Ct）<25 表示）和两者兼有的患者。我们从病历中检索了预先存在的条件和临床过程的信息。
我们发现了 727 名儿童中的 768 例感染，其中 496 例（64.6%）为男性，441 例（60.7%）为既往健康。中位年龄为 17.6 个月。大多数（476/768，62.0%）感染发生在 12 月至 3 月期间。HBoV1 在 549 例（71.5%）感染中与其他病毒合并感染。Ct<25 与年龄较小、HBoV1 单次检测和在流行季节早期出现有关。我们在各亚组之间的临床表现差异不大。
我们的研究结果与 HBoV1 原发性感染导致幼儿出现轻至重度呼吸道症状相一致。
