Wang Siyi, Wang Longyu, Shangguan Jiaolei, Jiang Ailiang, Ren Ang
Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.
Life (Basel). 2024 Oct 21;14(10):1339. doi: 10.3390/life14101339.
() is a traditional edible and medicinal mushroom in China. The main bioactive components in include triterpenoids, polysaccharides, steroids, and sterols. Ganoderic acids (GAs) are one of the most abundant triterpenoids found in , garnering significant attention from researchers in the fields of medicine and health care. We summarize the extensive studies on the physiological function of GAs in anti-cancer, anti-inflammatory, radiation protection, anti-aging, liver protection, anti-microbial, and neuroprotection areas, among others. This review provides a comprehensive overview of the recent advances in the bioactivities and pharmacological mechanisms of GAs, aiming to delineate the current research directions and the state of the art in this field. This analysis helps to rapidly identify new bioactivities of GAs and understand their mechanisms, leading to more effective treatments for various diseases.
（）是中国传统的食药用真菌。其主要生物活性成分包括三萜类、多糖、甾体和甾醇。灵芝酸（GAs）是在（）中发现的最丰富的三萜类之一，受到医学和医疗保健领域研究人员的极大关注。我们总结了关于灵芝酸在抗癌、抗炎、辐射防护、抗衰老、肝脏保护、抗菌和神经保护等生理功能方面的广泛研究。本综述全面概述了灵芝酸生物活性和药理机制的最新进展，旨在描绘该领域当前的研究方向和技术水平。该分析有助于快速识别灵芝酸的新生物活性并了解其机制，从而为各种疾病带来更有效的治疗方法。
