膳食补充酪蛋白/矢车菊素-3-O-葡萄糖苷纳米粒改变高脂肪喂养 C57BL/6 小鼠的肠道微生物群。
Dietary supplementation with casein/cyanidin-3-O-glucoside nanoparticles alters the gut microbiota in high-fat fed C57BL/6 mice.
机构信息
Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Pharmacognosy Group, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, Uppsala 751 23, Sweden.
出版信息
Food Chem. 2023 Jun 30;412:135494. doi: 10.1016/j.foodchem.2023.135494. Epub 2023 Jan 16.
This study aims to investigate the dietary intervention effect of casein/cyanidin-3-O-glucoside nanoparticles (Cs-C3G) on high-fat-diet (HFD)induced gut microbiota disorders. In HFD-fed C57BL/6mice, Cs-C3G has ameliorated HFD-caused fat accumulation and liver oxidative stress. Cs-C3G as a dietary supplementation can restore the abundance and diversity of gut microbiota with descending the ratio of Firmicutes to Bacteroidetes, increasing some beneficial microorganisms, and reducing some opportunistic pathogenic bacteria. In general, Cs-C3G has a effect on regulating the disturbance of gut microbiota, and then prevents HFD-induced obesity and liver damage.
本研究旨在探讨酪蛋白/矢车菊素-3-O-葡萄糖苷纳米粒（Cs-C3G）对高脂肪饮食（HFD）诱导的肠道菌群失调的饮食干预作用。在 HFD 喂养的 C57BL/6 小鼠中，Cs-C3G 改善了 HFD 引起的脂肪堆积和肝脏氧化应激。Cs-C3G 作为膳食补充剂可以恢复肠道微生物群的丰度和多样性，降低厚壁菌门与拟杆菌门的比例，增加一些有益微生物，减少一些机会性致病细菌。总的来说，Cs-C3G 对调节肠道菌群失调有一定的作用，从而预防 HFD 诱导的肥胖和肝损伤。
Zotero 插件