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美国各州大麻合法化状态下,2021 年成年人使用高浓度 Δ9-THC 大麻浓缩产品的情况。

Adult use of highly-potent Δ9-THC cannabis concentrate products by U.S. state cannabis legalization status, 2021.

机构信息

Department of Psychiatry, Columbia University Irving Medical Center, 1051 Riverside Drive, New York, NY 10032, USA; New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA; Department of Epidemiology, Columbia University Mailman School of Public Health, 722 W 168(th) St, New York, NY 10032, USA.

Department of Psychiatry, Dartmouth Geisel School of Medicine, One Medical Center Drive, Lebanon, NH 03756, USA.

出版信息

Addict Behav. 2023 May;140:107617. doi: 10.1016/j.addbeh.2023.107617. Epub 2023 Jan 10.

Abstract

BACKGROUND

Compared to plant/flower cannabis products, cannabis concentrates have higher average potency of delta-9-tetrahydrocannabinol (Δ9-THC), which may be associated with greater likelihood of cannabis-related harms. Information on factors associated with use of cannabis concentrates is needed.

METHODS

Respondents were 4,328 adult past-7-day cannabis users from all 50 U.S. states and Washington DC (DC) who participated in an online 2021 survey. Using logistic regression to generate adjusted odds ratios (aOR), we investigated whether participants in states that enacted recreational cannabis laws (RCL, 12 states plus DC [treated as a state], n = 1,236) or medical cannabis laws (MCL-only, 23 states, n = 2,030) by December 31, 2020 were more likely than those in states without cannabis laws (no-CL, 15 states, n = 1,062) to use cannabis concentrate products in the prior 7 days.

RESULTS

Most participants (92.4%) used plant material in the prior 7 days; 57.0% used cannabis concentrates. In RCL, MCL and no-CL states, concentrate use was reported by 61.5%, 56.6%, and 52.5%, respectively. Compared to participants in no-CL states, odds of using cannabis concentrate products were greater among those in RCL states (aOR = 1.47; CI = 1.17-1.84) and MCL-only states (aOR = 1.29; CI = 1.08-1.55). Whether states had legally-authorized dispensaries had little effect on results.

CONCLUSION

Results suggest that individuals in MCL-only and RCL states are more likely to use cannabis concentrate products. Determining mechanisms underlying these results, e.g., commercialization, could provide important information for prevention. Clinicians should be alert to patient use of concentrates, especially in MCL-only and RCL states. Continued monitoring is warranted as additional states legalize cannabis use.

摘要

背景

与植物/花卉大麻产品相比,大麻浓缩物的 Δ9-四氢大麻酚(Δ9-THC)平均效力更高,这可能与大麻相关危害的可能性更大有关。需要了解与使用大麻浓缩物相关的因素。

方法

本研究的参与者为来自美国所有 50 个州和华盛顿特区(DC)的 4328 名过去 7 天内使用过大麻的成年人,他们参加了 2021 年的一项在线调查。使用逻辑回归生成调整后的优势比(aOR),我们调查了在 2020 年 12 月 31 日之前颁布娱乐用大麻法(RCL,包括 12 个州和 DC[视为一个州],n=1236)或医用大麻法(MCL 仅,23 个州,n=2030)的州的参与者与没有大麻法的州(无-CL,15 个州,n=1062)的参与者相比,在过去 7 天内更有可能使用大麻浓缩物产品。

结果

大多数参与者(92.4%)在过去 7 天内使用过植物材料;57.0%的人使用过大麻浓缩物。在 RCL、MCL 和无-CL 州,分别有 61.5%、56.6%和 52.5%的参与者报告使用了浓缩物。与无-CL 州的参与者相比,RCL 州(aOR=1.47;CI=1.17-1.84)和 MCL 仅州(aOR=1.29;CI=1.08-1.55)的参与者使用大麻浓缩物产品的几率更大。各州是否有合法授权的药房对结果影响不大。

结论

结果表明,MCL 仅州和 RCL 州的个人更有可能使用大麻浓缩物产品。确定这些结果背后的机制,例如商业化,可能为预防提供重要信息。临床医生应该警惕患者使用浓缩物,尤其是在 MCL 仅州和 RCL 州。随着更多的州使大麻合法化,需要继续监测。

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