Zou Xiaoman, Sun Hongmei
Key Laboratory of Protected Horticulture of Education Ministry, College of Horticulture, Shenyang Agricultural University, Shenyang, China.
National and Local Joint Engineering Research Center of Northern Horticultural Facilities Design and Application Technology, Shenyang, China.
Front Plant Sci. 2023 Jan 20;14:1044918. doi: 10.3389/fpls.2023.1044918. eCollection 2023.
Plant biological processes, such as growth and metabolism, hormone signal transduction, and stress responses, are affected by gene transcriptional regulation. As gene expression regulators, transcription factors activate or inhibit target gene transcription by directly binding to downstream promoter elements. DOF (DNA binding with One Finger) is a classic transcription factor family exclusive to plants that is characterized by its single zinc finger structure. With breakthroughs in taxonomic studies of different species in recent years, many DOF members have been reported to play vital roles throughout the plant life cycle. They are not only involved in regulating hormone signals and various biotic or abiotic stress responses but are also reported to regulate many plant biological processes, such as dormancy, tissue differentiation, carbon and nitrogen assimilation, and carbohydrate metabolism. Nevertheless, some outstanding issues remain. This article mainly reviews the origin and evolution, protein structure, and functions of DOF members reported in studies published in many fields to clarify the direction for future research on DOF transcription factors.
植物的生物学过程，如生长与代谢、激素信号转导以及应激反应，均受基因转录调控的影响。作为基因表达调控因子，转录因子通过直接结合下游启动子元件来激活或抑制靶基因的转录。DOF（单指DNA结合）是植物特有的经典转录因子家族，其特征在于具有单一的锌指结构。近年来，随着不同物种分类学研究的突破，许多DOF成员被报道在植物的整个生命周期中发挥着至关重要的作用。它们不仅参与调节激素信号以及各种生物或非生物应激反应，还被报道调控许多植物生物学过程，如休眠、组织分化、碳氮同化以及碳水化合物代谢。然而，仍存在一些突出问题。本文主要综述众多领域发表的研究中报道的DOF成员的起源与进化、蛋白质结构及功能，以明确未来DOF转录因子的研究方向。
