Cui Minghua, Liu Yuehui, Men Xiaoping, Li Tao, Liu Da, Deng Yongzhi
Gynecology Department, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
Laboratory Department, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.
Front Cell Dev Biol. 2023 Jan 23;11:1110551. doi: 10.3389/fcell.2023.1110551. eCollection 2023.
Gynecological diseases are a series of diseases caused by abnormalities in the female reproductive organs or breast, which endanger women's fertility and even their lives. Therefore, it is important to investigate the mechanism of occurrence and treatment of gynecological diseases. Animal models are the main objects for people to study the development of diseases and explore treatment options. Large animals, compared to small rodents, have reproductive organs with structural and physiological characteristics closer to those of humans, and are also better suited for long-term serial examinations for gynecological disease studies. This review gives examples of large animal models in gynecological diseases and provides a reference for the selection of animal models for gynecological diseases.
妇科疾病是由女性生殖器官或乳房异常引起的一系列疾病，危及女性生育能力甚至生命。因此，研究妇科疾病的发生机制和治疗方法很重要。动物模型是人们研究疾病发展和探索治疗方案的主要对象。与小型啮齿动物相比，大型动物的生殖器官在结构和生理特征上更接近人类，也更适合进行妇科疾病研究的长期连续检查。本文综述列举了妇科疾病大型动物模型的实例，为妇科疾病动物模型的选择提供参考。
