OBJECTIVES: Thin-slice prostate MRI might be beneficial for prostate cancer diagnostics. However, prolongation of acquisition time is a major drawback of thin-slice imaging. Therefore, the purpose of this study was to investigate the impact of a thin-slice deep learning accelerated T2-weighted (w) TSE imaging sequence (T2) of the prostate as compared to conventional T2w TSE imaging (T2). MATERIALS AND METHODS: Thirty patients were included in this prospective study at one university center after obtaining written informed consent. T2 (3 mm slice thickness) was acquired first in three orthogonal planes followed by thin-slice T2 (2 mm slice thickness) in axial plane. Acquisition time of axial conventional T2 was 4:12 min compared to 4:37 min for T2. Imaging datasets were evaluated by two radiologists using a Likert-scale ranging from 1-4, with 4 being the best regarding the following parameters: sharpness, lesion detectability, artifacts, overall image quality, and diagnostic confidence. Furthermore, preference of T2 versus T2 was evaluated. RESULTS: The mean patient age was 68 ± 8 years. Sharpness of images and lesion detectability were rated better in T2 with a median of 4 versus a median of 3 in T2 ( < 0.001 for both readers). Image noise was evaluated to be significantly worse in T2 as compared to T2 ( < 0.001 and = 0.021, respectively). Overall image quality was also evaluated to be superior in T2 versus T2 with a median of 4 versus 3 ( < 0.001 for both readers). Both readers chose T2 in 29 cases as their preference. CONCLUSIONS: Thin-slice T2 of the prostate provides a significant improvement of image quality without significant prolongation of acquisition time.