Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.
Int J Mol Sci. 2023 Jan 27;24(3):2478. doi: 10.3390/ijms24032478.
Serum amyloid A (SAA) is a good systemic marker of the exacerbations of chronic obstructive pulmonary disease (COPD), but the significance of SAA in stable patients with COPD has not been widely investigated. We aimed to evaluate the SAA level in peripheral blood from stable patients with COPD and to search for correlations between SAA and other inflammatory markers and clinical characteristics of the disease. Serum SAA, IL-6, IL-8, TNF-alpha, basic blood investigations, pulmonary function testing and a 6-min walk test were performed. The correlations between SAA and other inflammatory markers, functional performance and the number of disease exacerbations were evaluated. A total of 100 consecutive patients with COPD were analyzed. No correlations between SAA and inflammatory markers as well as pulmonary function were found. Hierarchical clustering identified two clusters incorporating SAA: one comprised SAA, PaO and FEV and the second was formed of SAA and nine other disease markers. The SAA level was higher in patients with blood eosinophils < 2% when compared to those with blood eosinophils ≥ 2% (41.8 (19.5-69.7) ng/mL vs. 18.9 (1.0-54.5) ng/mL, respectively, = 0.04). We conclude that, in combination with other important disease features, SAA may be useful for patient evaluation in stable COPD.
血清淀粉样蛋白 A（SAA）是慢性阻塞性肺疾病（COPD）加重的良好全身标志物，但 SAA 在稳定期 COPD 患者中的意义尚未得到广泛研究。我们旨在评估稳定期 COPD 患者外周血中的 SAA 水平，并寻找 SAA 与其他炎症标志物和疾病临床特征之间的相关性。进行了血清 SAA、IL-6、IL-8、TNF-α、基础血液检查、肺功能测试和 6 分钟步行测试。评估了 SAA 与其他炎症标志物、功能表现和疾病加重次数之间的相关性。分析了 100 例连续的 COPD 患者。SAA 与炎症标志物以及肺功能均无相关性。分层聚类确定了包含 SAA 的两个聚类：一个包含 SAA、PaO 和 FEV，另一个由 SAA 和其他九个疾病标志物组成。与血液嗜酸性粒细胞≥2%的患者相比，血液嗜酸性粒细胞<2%的患者 SAA 水平更高（分别为 41.8（19.5-69.7）ng/mL 和 18.9（1.0-54.5）ng/mL， = 0.04）。我们的结论是，SAA 与其他重要疾病特征相结合，可能对稳定期 COPD 患者的评估有用。
