Moskvitina Ekaterina, Kuznetsov Vladimir, Moseenkov Sergey, Serkova Aleksandra, Zavorin Alexey
Siberian Federal Research and Clinical Center of FMBA of Russia, 636000 Tomsk, Russia.
Boreskov Institute of Catalysis SB RAS, 630090 Novosibirsk, Russia.
Materials (Basel). 2023 Jan 19;16(3):957. doi: 10.3390/ma16030957.
The increasing resistance of bacteria and fungi to antibiotics is one of the health threats facing humanity. Of great importance is the development of new antibacterial agents or alternative approaches to reduce bacterial resistance to available antibacterial drugs. Due to the complexity of their properties, carbon nanomaterials (CNMs) may be of interest for a number of biomedical applications. One of the problems in studying the action of CNMs on microorganisms is the lack of universally standardized methods and criteria for assessing antibacterial and antifungal activity. In this work, using a unified methodology, a comparative study of the antimicrobial properties of the CNM systemic kit against common opportunistic microorganisms, namely and , was carried out. Multiwalled carbon nanotubes (MWNTs), catalytic filamentous carbon with different orientations of graphene blocks (coaxial-conical and stacked, CFC), ionic carbon (OLC), and ultrafine explosive nanodiamonds (NDs) were used as a system set of CNMs. The highest antimicrobial activity was shown by NDs, both types of CFCs, and carboxylated hydrophilic MWCNTs. The SEM results point out the difference between the mechanisms of action of UDD and CFC nanotubes.
细菌和真菌对抗生素的耐药性不断增强是人类面临的健康威胁之一。开发新型抗菌剂或采用替代方法以降低细菌对现有抗菌药物的耐药性至关重要。由于其性质复杂，碳纳米材料（CNMs）在许多生物医学应用中可能具有吸引力。研究碳纳米材料对微生物作用的问题之一是缺乏评估抗菌和抗真菌活性的通用标准化方法和标准。在这项工作中，采用统一的方法，对碳纳米材料系统套件对常见机会性微生物（即 和 ）的抗菌性能进行了比较研究。多壁碳纳米管（MWNTs）、具有不同石墨烯块取向的催化丝状碳（同轴锥形和堆叠式，CFC）、离子碳（OLC）和超细爆炸纳米金刚石（NDs）被用作碳纳米材料的系统套件。纳米金刚石、两种类型的CFC以及羧基化亲水性多壁碳纳米管表现出最高的抗菌活性。扫描电子显微镜（SEM）结果指出了超分散金刚石（UDD）和CFC纳米管作用机制的差异。
