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基于交联微生物多糖的新型纳米复合水凝胶作为潜在的生物活性伤口敷料

Novel Nanocomposite Hydrogels Based on Crosslinked Microbial Polysaccharide as Potential Bioactive Wound Dressings.

作者信息

Marin Maria Minodora, Albu Kaya Madalina, Kaya Durmus Alpaslan, Constantinescu Roxana, Trica Bogdan, Gifu Ioana Catalina, Alexandrescu Elvira, Nistor Cristina Lavinia, Alexa Rebeca Leu, Ianchis Raluca

机构信息

National Research and Development Institute for Textile and Leather, Division Leather and Footwear Research Institute, Department of Collagen, 93 Ion Minulescu Str., 031215 Bucharest, Romania.

Advanced Polymer Materials Group, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 1-7 Polizu Street, 01106 Bucharest, Romania.

出版信息

Materials (Basel). 2023 Jan 20;16(3):982. doi: 10.3390/ma16030982.

DOI:10.3390/ma16030982
PMID:36769988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9920030/
Abstract

A multitude of dressings have been developed to promote wound repair, such as membranes, foams, hydrocolloids and hydrogels. In this study, a crosslinked polysaccharide hydrogel was mixed with a bioactive ingredient to synthesize a novel nanocomposite material to be used in wound healing. Variation of the ratio between hydrogel components was followed and its effect was analyzed in regard to swelling, degradation rate and thermo-mechanical behavior. The resulting crosslinked structures were characterized by FTIR and microscopy analyses. The antimicrobial activity of the crosslinked hydrogels loaded with bioactive agent was evaluated using two bacterial strains (Gram-positive Staphylococcus aureus and Gram-negative bacteria Escherichia Coli). All the results showed that the new synthesized biopolymer nanocomposites have adequate properties to be used as antibacterial wound dressings.

摘要

为促进伤口愈合，人们已研发出多种敷料，如薄膜、泡沫、水胶体和水凝胶。在本研究中，将一种交联多糖水凝胶与一种生物活性成分混合，以合成一种用于伤口愈合的新型纳米复合材料。研究了水凝胶成分之间比例的变化，并分析了其对膨胀、降解速率和热机械行为的影响。通过傅里叶变换红外光谱（FTIR）和显微镜分析对所得交联结构进行了表征。使用两种细菌菌株（革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌）评估了负载生物活性剂的交联水凝胶的抗菌活性。所有结果表明，新合成的生物聚合物纳米复合材料具有足够的性能，可作为抗菌伤口敷料使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/14be1d63f5bf/materials-16-00982-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/297c28be1a32/materials-16-00982-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/b510ae2470b5/materials-16-00982-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/2d403c9d17e5/materials-16-00982-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/0a6a2503244f/materials-16-00982-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/dd44575ad260/materials-16-00982-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/5e9fbdc9b95d/materials-16-00982-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/93e1bfb6fa74/materials-16-00982-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/14be1d63f5bf/materials-16-00982-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/297c28be1a32/materials-16-00982-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/b510ae2470b5/materials-16-00982-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/2d403c9d17e5/materials-16-00982-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/0a6a2503244f/materials-16-00982-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/dd44575ad260/materials-16-00982-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/5e9fbdc9b95d/materials-16-00982-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/93e1bfb6fa74/materials-16-00982-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a3c/9920030/14be1d63f5bf/materials-16-00982-g008.jpg

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Novel Nanocomposite Hydrogels Based on Crosslinked Microbial Polysaccharide as Potential Bioactive Wound Dressings.

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引用本文的文献

[1]
Cellulose Acetate-Based Wound Dressings Loaded with Bioactive Agents: Potential Scaffolds for Wound Dressing and Skin Regeneration.

Curr Drug Deliv. 2024

[2]
Microbial Polysaccharide-Based Formulation with Silica Nanoparticles; A New Hydrogel Nanocomposite for 3D Printing.

Gels. 2023-5-19

本文引用的文献

[1]
Novel Green Crosslinked Salecan Hydrogels and Preliminary Investigation of Their Use in 3D Printing.

Pharmaceutics. 2023-1-21

[2]
Synthesis and Rheological Characterization of a Novel Salecan Hydrogel.

Pharmaceutics. 2022-7-18

[3]
Novel antibacterial hydrogels based on gelatin/polyvinyl-alcohol and graphene oxide/silver nanoconjugates: formulation, characterization, and preliminary biocompatibility evaluation.

Heliyon. 2022-3-21

[4]
Sustainable Mitigation of Paracetamol with a Novel Dual-Functionalized Pullulan/Kaolin Hydrogel Nanocomposite from Simulated Wastewater.

Langmuir. 2022-7-12

[5]
Citric acid crosslinked sphingan WL gum hydrogel films supported ciprofloxacin for potential wound dressing application.

Carbohydr Polym. 2022-9-1

[6]
Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies.

Drug Deliv Transl Res. 2022-8

[7]
Hydrogel Preparation Methods and Biomaterials for Wound Dressing.

Life (Basel). 2021-9-27

[8]
Oxidation triggered formation of polydopamine-modified carboxymethyl cellulose hydrogel for anti-recurrence of tumor.

Colloids Surf B Biointerfaces. 2021-11

[9]
A New Dermal Substitute Containing Polyvinyl Alcohol with Silver Nanoparticles and Collagen with Hyaluronic Acid: In Vitro and In Vivo Approaches.

Antibiotics (Basel). 2021-6-19

[10]
The Effects of Monomer, Crosslinking Agent, and Filler Concentrations on the Viscoelastic and Swelling Properties of Poly(methacrylic acid) Hydrogels: A Comparison.

Materials (Basel). 2021-4-29

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