Jarvie D R, Thompson A M, Dyson E H
Department of Clinical Chemistry, Royal Infirmary, Edinburgh, Scotland, UK.
Clin Chim Acta. 1987 Oct 15;168(3):313-22. doi: 10.1016/0009-8981(87)90007-6.
A method has been developed for the simultaneous determination of the sympathomimetic drugs salbutamol and terbutaline in the plasma of poisoned patients, using ion-pair high-performance liquid chromatography with amperometric detection. Plasma concentrations of the drugs, measured in 8 poisoned patients, were well above the therapeutic range. The clinical and metabolic effects of overdose with these drugs were considerably less severe than those seen in patients with plasma theophylline concentrations elevated to the same degree.
已开发出一种方法，采用离子对高效液相色谱-安培检测法同时测定中毒患者血浆中的拟交感神经药物沙丁胺醇和特布他林。在8名中毒患者中测得的药物血浆浓度远高于治疗范围。与血浆茶碱浓度升高到相同程度的患者相比，这些药物过量服用的临床和代谢影响要轻得多。
