Department of Psychology, New York University, New York, New York.
Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel; Department of Cognitive and Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Biol Psychiatry. 2023 Apr 15;93(8):739-750. doi: 10.1016/j.biopsych.2023.02.004. Epub 2023 Feb 10.
A central goal of computational psychiatry is to identify systematic relationships between transdiagnostic dimensions of psychiatric symptomatology and the latent learning and decision-making computations that inform individuals' thoughts, feelings, and choices. Most psychiatric disorders emerge prior to adulthood, yet little work has extended these computational approaches to study the development of psychopathology. Here, we lay out a roadmap for future studies implementing this approach by developing empirically and theoretically informed hypotheses about how developmental changes in model-based control of action and Pavlovian learning processes may modulate vulnerability to anxiety and addiction. We highlight how insights from studies leveraging computational approaches to characterize the normative developmental trajectories of clinically relevant learning and decision-making processes may suggest promising avenues for future developmental computational psychiatry research.
计算精神病学的一个核心目标是确定精神症状的跨诊断维度与潜在学习和决策计算之间的系统关系,这些计算为个体的思想、感觉和选择提供信息。大多数精神障碍在成年前就出现了,但很少有工作将这些计算方法扩展到研究精神病理学的发展。在这里,我们通过提出关于基于模型的行为控制和条件反射学习过程的发展变化如何调节焦虑和成瘾易感性的经验和理论上有根据的假设,为未来实施这种方法的研究制定了路线图。我们强调了利用计算方法来描述与临床相关的学习和决策过程的正常发展轨迹的研究可以为未来的发展计算精神病学研究提供有希望的途径。