海洛因成瘾者的降钙素和催乳素血清水平：对美沙酮治疗组的研究

Calcitonin and prolactin serum levels in heroin addicts: study on a methadone treated group.

作者信息

Spagnolli W, Torboli P, Mattarei M, De Venuto G, Marcolla A, Miori R

机构信息

Divisione Medica 1, Istituti Ospedalieri, Trento, Italy.

出版信息

Drug Alcohol Depend. 1987 Nov;20(2):143-8. doi: 10.1016/0376-8716(87)90063-9.

DOI:10.1016/0376-8716(87)90063-9

PMID:3678052

Abstract

Serum calcitonin (CT) and prolactin (PRL) levels were determined in 21 heroin addicts in hospital treatment with methadone. After withdrawal of heroin the values of CT 112.4 +/- 62.9 pg/ml, and PRL 19.1 +/- 10.1 ng/ml were both significantly higher (P less than 0.001) than in normal controls (62.2 +/- 43.8 pg/ml and 9.1 +/- 3.5 ng/ml, respectively). After withdrawal of methadone, i.e. 12 +/- 3.7 days after heroin withdrawal, CT values were 76.6 +/- 32.7 ng/ml (a significant level of P less than 0.02 towards initial values). No correlation was noted between CT and PRL values.

摘要

对21名正在接受美沙酮住院治疗的海洛因成瘾者测定了血清降钙素（CT）和催乳素（PRL）水平。停用海洛因后，CT值为112.4±62.9 pg/ml，PRL值为19.1±10.1 ng/ml，两者均显著高于正常对照组（分别为62.2±43.8 pg/ml和9.1±3.5 ng/ml，P<0.001）。停用美沙酮后，即停用海洛因12±3.7天后，CT值为76.6±32.7 ng/ml（与初始值相比P<0.02，差异有统计学意义）。未发现CT值与PRL值之间存在相关性。