Opt Express. 2023 Jan 30;31(3):4319-4333. doi: 10.1364/OE.477258.
Future healthcare and precision medicine require multiplex and reliable biosensors. Here we present a compact photonic crystal based microdisk biosensor that is designed for simultaneous intensity and phase measurements of multiple biomarkers in parallel. The combination of two different measurement approaches has a range of advantages. Phase detection has higher signal to noise ratios, while intensity measurement helps to align the sensor to high phase sensitivities and increase the reliability. The performance of the microdisk biosensor system is examined by simulations and measurements. For proof of concept, parallel intensity and phase shifts are measured upon binding of human-alpha-thrombin and streptavidin.
未来的医疗和精准医学需要多路复用和可靠的生物传感器。在这里，我们提出了一种基于光子晶体的微型盘生物传感器，该传感器设计用于同时对多个生物标志物进行并行的强度和相位测量。两种不同测量方法的结合具有多种优势。相位检测具有更高的信噪比，而强度测量有助于将传感器与高相位灵敏度对齐，并提高可靠性。通过仿真和测量来检验微盘生物传感器系统的性能。为了验证概念，在人凝血酶和链霉亲和素结合时，同时测量了并行的强度和相位偏移。
