School of Pharmacy, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, People's Republic of China.
Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, 28 Western Changsheng Road, Hengyang, Hunan 421001, People's Republic of China.
Comb Chem High Throughput Screen. 2023;26(13):2267-2279. doi: 10.2174/1386207326666230213141627.
Gastric cancer is one of the most common and highest mortality rate cancers in the world. Exosomes are vesicles secreted by cells carrying different types of molecules, such as protein and RNA. Numerous studies have confirmed that exosomes are involved in various stages of the occurrence and development of gastric cancer and play an important role. With the gradual development, exosomes have been widely employed in the diagnosis and treatment of gastric cancer. In this review, we have provided a basic overview of exosome, and discussed the role of exosome in the occurrence, proliferation, invasion, metastasis, and drug resistance in gastric cancer. In addition, we have emphasized the bright development prospect of exosome in the diagnosis and treatment of gastric cancer. The data on the discovery, diagnosis, treatment, and prognosis of gastric cancer are not particularly optimistic, but the discovery of exosome, applied in diagnosis and treatment, provides a new and effective way to improve the survival rate of patients with gastric cancer.
胃癌是世界上最常见和死亡率最高的癌症之一。外泌体是细胞分泌的囊泡,携带不同类型的分子,如蛋白质和 RNA。大量研究证实,外泌体参与胃癌发生发展的各个阶段,发挥重要作用。随着研究的逐步深入,外泌体已广泛应用于胃癌的诊断和治疗。在本综述中,我们对外泌体进行了基本概述,并讨论了外泌体在胃癌发生、增殖、侵袭、转移和耐药中的作用。此外,我们强调了外泌体在胃癌诊断和治疗中的广阔发展前景。胃癌的发现、诊断、治疗和预后数据并不特别乐观,但外泌体的发现及其在诊断和治疗中的应用为提高胃癌患者的生存率提供了一种新的、有效的途径。