Yousefi Rizi Hossein Ali, Hoon Shin Dong, Yousefi Rizi Shima
Department of Mechanical System Engineering, Kookmin University, Seoul, 136-702, South Korea.
Department of Occupational Health Engineering, Isfahan University of Medical Sciences, Isfahan, Iran.
Iran J Public Health. 2022 Feb;51(2):226-239. doi: 10.18502/ijph.v51i2.8677.
Chemotherapy is a common treatment technique that uses chemical drugs to kill cancer cells. This technique affects normal healthy tissues being unspecific and has toxic adverse effects. Nowadays, nanotechnology applications in cancer chemotherapy have helped to solve the uncontrolled problems involving distribution of medicine particles and other side effects. Nanoparticles (NPs) can offer significant advantages over conventional drug delivery to have magnificent properties such as controlled mode of action, various methods of administration, and the ability to transport both organic/inorganic drug particles. Special ligands containing polymeric NPs preferentially hit the tumour site because of their chemical affinity to malignant tissues. This article, reviews the fabrication, characterization, and applications of NPs being used in chemotherapy. Furthermore, different forms of polymeric and especially polymeric chemotherapy were also explored and discussed to understand better the effects of NPs on cancer chemotherapy.
化疗是一种常用的治疗技术，它使用化学药物来杀死癌细胞。该技术具有非特异性，会影响正常健康组织，并且具有毒性副作用。如今，纳米技术在癌症化疗中的应用有助于解决药物颗粒分布失控及其他副作用等问题。与传统药物递送相比，纳米颗粒（NPs）具有显著优势，具有诸如可控作用模式、多种给药方式以及运输有机/无机药物颗粒的能力等优异特性。含有聚合物纳米颗粒的特殊配体由于其对恶性组织的化学亲和力而优先作用于肿瘤部位。本文综述了用于化疗的纳米颗粒的制备、表征及应用。此外，还探讨和讨论了不同形式的聚合物，特别是聚合物化疗，以便更好地理解纳米颗粒对癌症化疗的影响。
