Badar Faraz, Cheema Muhammad Azaz I, Iftikhar Asma
Internal Medicine, Northwell Health at Mather Hospital, Port Jefferson, USA.
Pulmonary and Critical Care Medicine, Northwell Health at Mather Hospital, Port Jefferson, USA.
Cureus. 2023 Jan 13;15(1):e33753. doi: 10.7759/cureus.33753. eCollection 2023 Jan.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) has been reported to cause significant injury to the central nervous system (CNS). Herein, we describe the case of a 48-year-old male with a past medical history of attention-deficit/hyperactivity disorder (ADHD), hypertension, and hyperlipidemia who developed typical symptomatology of normal pressure hydrocephalus (NPH) with cognitive impairment, gait dysfunction, and urinary incontinence after a mild coronavirus disease (COVID-19) infection. The diagnosis was confirmed by imaging and lumbar puncture (LP). The patient was treated with a ventriculoperitoneal (VP) shunt placed by neurosurgery and had a complete recovery. Despite increasing reports of neurological manifestations of COVID-19 infection, the mechanism of such pathology is still not well understood. Hypotheses include viral invasion of the CNS either through the nasopharynx and olfactory epithelium or directly through the blood brain barrier.
据报道，严重急性呼吸综合征冠状病毒2（SARS-CoV-2病毒）会对中枢神经系统（CNS）造成严重损伤。在此，我们描述了一名48岁男性的病例，该患者既往有注意力缺陷多动障碍（ADHD）、高血压和高脂血症病史，在轻度冠状病毒病（COVID-19）感染后出现了正常压力脑积水（NPH）的典型症状，包括认知障碍、步态功能障碍和尿失禁。通过影像学检查和腰椎穿刺（LP）确诊。该患者接受了神经外科放置的脑室腹腔（VP）分流术治疗，并完全康复。尽管关于COVID-19感染神经表现的报道越来越多，但这种病理机制仍未完全明确。假说包括病毒通过鼻咽和嗅上皮侵入中枢神经系统，或直接穿过血脑屏障。
