Centre for Health Management and Policy Research, School of Public Health，Cheeloo College of Medicine, Shandong University, Jinan, China.
NHC Key Lab of Health Economics and Policy Research, Shandong University, Jinan, China.
Hum Vaccin Immunother. 2023 Dec 31;19(1):2179222. doi: 10.1080/21645515.2023.2179222. Epub 2023 Feb 15.
Rotavirus vaccination is the most effective means to prevent rotavirus gastroenteritis, but its coverage in China is not ideal. We aimed to explore parental preferences for rotavirus vaccination for their children under 5years old to improve vaccination coverage. A Discrete Choice Experiment was conducted online on 415 parents with at least one child under 5years old in 3 cities. Five attributes including vaccine effectiveness, protection duration, risk of mild side-effects, out-of-pocket costs, and time required for vaccination were identified. Each attribute was set at three levels. Mixed-logit models were used to measure parental preferences and the relative importance of vaccine attributes. The optimal vaccination strategy was also explored. 359 samples were included in the analysis. The impacts of the vaccine attribute levels on vaccine choice were all statistically significant ( < .01), except for 1-hour vaccination time. The risk of mild side-effects was the most important factor influencing vaccination. The time required for vaccination was the least important attribute. The largest increase in vaccination uptake (74.45%) occurred with decreased the vaccine risk of mild side-effects from 1/10 to 1/50. The predicted vaccination uptake of the optimal vaccination scenario was 91.79%. When deciding about vaccination, parents preferred the rotavirus vaccination with lower risk of mild side-effects, higher effectiveness, longer protection duration, 2-hour vaccination time and lower cost. The authorities should support enterprises to develop vaccines with lower side-effects, higher effectiveness and longer protection duration in the future. We call for appropriate government subsidies for the rotavirus vaccine.
轮状病毒疫苗接种是预防轮状病毒胃肠炎最有效的手段，但在中国的覆盖率并不理想。本研究旨在探讨父母对 5 岁以下儿童接种轮状病毒疫苗的偏好，以提高疫苗接种率。在三个城市进行了一项在线离散选择实验，共纳入 415 名至少有一名 5 岁以下儿童的家长。确定了疫苗效力、保护持续时间、轻度副作用风险、自付费用和接种所需时间 5 个属性，每个属性设置 3 个水平。使用混合 Logit 模型来衡量父母的偏好和疫苗属性的相对重要性，并探索最佳的疫苗接种策略。共纳入 359 个样本进行分析。疫苗属性水平对疫苗选择的影响均具有统计学意义（ < .01），除了接种时间 1 小时。轻度副作用风险是影响接种的最重要因素。接种所需时间是最不重要的属性。随着轻度副作用风险从 1/10 降低到 1/50，疫苗接种率增加了 74.45%。最佳接种方案预测的疫苗接种率为 91.79%。在决定接种时，父母更喜欢副作用风险较低、效力较高、保护持续时间较长、接种时间为 2 小时、成本较低的轮状病毒疫苗。未来，主管部门应支持企业开发副作用更低、效力更高、保护持续时间更长的疫苗。我们呼吁政府为轮状病毒疫苗提供适当的补贴。
