Division of Behavioural Sciences, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Vaccine. 2020 Jun 15;38(29):4557-4563. doi: 10.1016/j.vaccine.2020.05.012. Epub 2020 May 7.
This study examined the relative importance of factors relating to vaccine characteristics, social normative influence and convenience in access to vaccine for determining decision making for seasonal influenza vaccination (SIV) among healthcare personnel (HCP), aiming to optimize existing influenza vaccination programmes for HCP.
A discrete choice experiment (DCE) was conducted in HCP working in public hospitals in Hong Kong. The DCE was designed to examine the relative importance of vaccine characteristics (vaccine efficacy and safety), social normative influence reflected by the proportion of HCP colleagues intending to take SIV, and convenience in access to vaccine indicated by vaccination programme duration, vaccination location, vaccination arrangement procedure and service hours in determining influenza vaccination choice among HCP. Mixed logit regression modelling was conducted to examine the preference weight (β) of factors included in the DCE for determining vaccination choice.
Vaccination probability increased with increase in vaccine efficacy (β = 0.02 for per 1% increase), vaccination location changing from "designated staff clinic" to "mobile station" (β = 0.37), vaccination arrangement procedure changing from "by appointment" to "by walk-in" (β = 0.99), but decreased with the increase in probability of mild reactions to vaccination (β = -0.05 for per 1% increase).
Vaccine safety was judged to be more important than vaccine efficacy for determining vaccination choice. Arranging vaccination service by walk-in and implementing mobile vaccination station should be considered in future SIV programmes to compensate for the effect of perceived low vaccination efficacy and concerns about vaccine safety to promote SIV uptake among HCP.
本研究旨在探讨疫苗特性、社会规范影响和接种便利性等因素在医疗保健人员（HCP）季节性流感疫苗接种（SIV）决策中的相对重要性，旨在优化现有的 HCP 流感疫苗接种计划。
在香港公立医院工作的 HCP 中进行了一项离散选择实验（DCE）。DCE 旨在研究疫苗特性（疫苗效力和安全性）、反映 HCP 同事打算接种 SIV 的比例的社会规范影响、以及接种疫苗的便利性（疫苗接种计划持续时间、接种地点、接种安排程序和服务时间）在确定 HCP 流感疫苗接种选择方面的相对重要性。采用混合 logit 回归模型来检验 DCE 中用于确定接种选择的因素的偏好权重（β）。
疫苗接种概率随疫苗效力的增加而增加（每增加 1%，β=0.02），接种地点从“指定员工诊所”变为“流动站”（β=0.37），接种安排程序从“预约”变为“随到随打”（β=0.99），但随着对疫苗轻度反应概率的增加而降低（每增加 1%，β=-0.05）。
在确定接种选择时，疫苗安全性被认为比疫苗效力更重要。在未来的 SIV 计划中，应考虑通过随到随打安排接种服务并实施移动接种站，以弥补疫苗接种效果低和对疫苗安全性的担忧的影响，从而促进 HCP 接种 SIV。
