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在英国工作的兽医对犬用扑热息痛的认知和使用情况。

Current perceptions and use of paracetamol in dogs among veterinary surgeons working in the United Kingdom.

机构信息

Department of Small Animal Medicine, Pride Veterinary Centre, IVC Evidensia, Derby, UK.

出版信息

Vet Med Sci. 2023 Mar;9(2):679-686. doi: 10.1002/vms3.1058. Epub 2023 Feb 16.

DOI:10.1002/vms3.1058
PMID:36798030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10029871/
Abstract

BACKGROUND

Paracetamol (acetaminophen) is recommended as a first-line drug in the management of pain and pyrexia in humans due to its minor gastrointestinal, renal and vascular side effects.

OBJECTIVES

To explore the perceptions and use of paracetamol in dogs by UK veterinarians.

METHODS

Veterinarians were invited to complete an online survey. Questions addressed career history, previous use, and personal perceptions of the use of paracetamol in dogs.

RESULTS

A total of 450 veterinarians were included in the survey; 96% (n = 431) of whom worked in small animal practice only. The majority reported a frequency of use of 1-3 times a week (n = 197), with oral dosing being the most common route of administration (n = 440). Only 8 had never prescribed paracetamol. Paracetamol was more commonly used to provide analgesia (n = 431) than for the treatment of pyrexia (n = 292) and was predominantly used as an alternative to NSAIDs (n = 408) or as part of multimodal analgesia (n = 406). Hepatotoxic (n = 311) and gastrointestinal (n = 120) side effects were a common concern, although the majority perceived a low risk of side effects and felt they were likely to be mild if they did occur (n = 279). Only 5% (n = 24) of respondents reported having experienced side effects, with gastrointestinal signs (n = 14) and hepatotoxicity (n = 6) being the most common.

CONCLUSIONS

Paracetamol is widely used by veterinarians working in the UK. Most veterinarians have changed their perception on the use of paracetamol over the last decade and consider it to be associated with fewer side effects and with more effective analgesic and antipyretic effects than they had previously believed.

摘要

背景

由于对胃肠道、肾脏和血管的副作用较小，扑热息痛（对乙酰氨基酚）在人类疼痛和发热的治疗中被推荐为一线药物。

目的

探索英国兽医对犬用扑热息痛的认知和使用情况。

方法

兽医受邀参与在线调查。问题涉及职业生涯、既往使用情况以及个人对犬用扑热息痛使用的看法。

结果

共有 450 名兽医参与了这项调查；其中 96%（n=431）仅从事小动物临床工作。大多数兽医报告的使用频率为每周 1-3 次（n=197），最常见的给药途径是口服（n=440）。仅有 8 名兽医从未开处过扑热息痛。兽医更常将扑热息痛用于镇痛（n=431），而非退热（n=292），主要将其作为 NSAIDs 的替代品（n=408）或作为多模式镇痛的一部分（n=406）。肝毒性（n=311）和胃肠道（n=120）副作用是常见的顾虑，但大多数兽医认为副作用风险较低，如果发生副作用，也可能是轻微的（n=279）。只有 5%（n=24）的受访者报告出现过副作用，最常见的是胃肠道症状（n=14）和肝毒性（n=6）。

结论

扑热息痛在英国工作的兽医中广泛使用。在过去十年中，大多数兽医改变了他们对扑热息痛使用的看法，认为它的副作用更少，且具有比他们以前认为更有效的镇痛和解热效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/1a8aa5acac3f/VMS3-9-679-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/f875435d02ff/VMS3-9-679-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/6a197553668f/VMS3-9-679-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/e6cdeaba17de/VMS3-9-679-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/99e81f7c7335/VMS3-9-679-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/385ddc184766/VMS3-9-679-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/d75ab76427be/VMS3-9-679-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/4249c793fe0d/VMS3-9-679-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/1a8aa5acac3f/VMS3-9-679-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/f875435d02ff/VMS3-9-679-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/6a197553668f/VMS3-9-679-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/e6cdeaba17de/VMS3-9-679-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/99e81f7c7335/VMS3-9-679-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/385ddc184766/VMS3-9-679-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/d75ab76427be/VMS3-9-679-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/4249c793fe0d/VMS3-9-679-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7fc/10029871/1a8aa5acac3f/VMS3-9-679-g006.jpg

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3
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4
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