受氨基酸影响的肿瘤微环境和肿瘤免疫。
Influenced tumor microenvironment and tumor immunity by amino acids.
机构信息
Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Sichuan, Chengdu, China.
出版信息
Front Immunol. 2023 Jan 31;14:1118448. doi: 10.3389/fimmu.2023.1118448. eCollection 2023.
It is widely accepted that tumors are a complex tissue composed of cancer cells, extracellular matrix, inflammatory cells, immune cells, and other cells. Deregulation of tumor microenvironment promotes tumor aggressiveness by sustaining cell growth, invasion, and survival from immune surveillance. The concepts that some dietary nutrients could change tumor microenvironment are extremely attractive. Many studies demonstrated that high-fat diet-induced obesity shaped metabolism to suppress anti-tumor immunity, but how amino acids changed the tumor microenvironment and impacted tumor immunity was still not totally understood. In fact, amino acid metabolism in different signaling pathways and their cross-talk shaped tumor immunity and therapy efficacy in cancer patients. Our review focused on mechanisms by which amino acid influenced tumor microenvironment, and found potential drug targets for immunotherapy in cancer.
人们普遍认为，肿瘤是一种由癌细胞、细胞外基质、炎性细胞、免疫细胞和其他细胞组成的复杂组织。肿瘤微环境的失调通过维持细胞生长、侵袭和逃避免疫监视来促进肿瘤的侵袭性。一些膳食营养素可以改变肿瘤微环境的观点极具吸引力。许多研究表明，高脂肪饮食诱导的肥胖改变了代谢，从而抑制了抗肿瘤免疫，但氨基酸如何改变肿瘤微环境并影响肿瘤免疫仍不完全清楚。事实上，不同信号通路中的氨基酸代谢及其相互作用塑造了肿瘤免疫和癌症患者的治疗效果。我们的综述重点关注了氨基酸影响肿瘤微环境的机制，并发现了癌症免疫治疗的潜在药物靶点。
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